Evaluation of the presence of enterotoxin b in bacteria from the nasal mucosa of patients with chronic rhinosinusitis with exposure to cotton fiber

• Grant number: 14/17179-6
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2015
• End date: February 28, 2017
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Wilma Terezinha Anselmo Lima
• Grantee: Wilma Terezinha Anselmo Lima
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Edwin Tamashiro ; Fabiana Cardoso Pereira Valera ; Ivan de Picoli Dantas

Abstract

Exposure to occupational allergens and irritating factors, such as cotton, can trigger various respiratory manifestations such as Occupational Asthma and Rhinitis, and lacking studied this association as "occupational exposure to allergen - chronic rhinosinusitis (CRS)" in our midst. It is an experimental research in order to determine the presence of Staphylococcus enterotoxins B (SED) of bacteria in the nasal mucosa of patients with CRS and who are workers of the textile industry, where the main exposure in occupational settings is with fiber cotton. The SED are considered influential in shaping the framework of CSR. As a secondary objective will be performed on the same samples, immunohistochemical analysis of IL-17 and IL-33. Methods: Three groups will be developed for the research. The first with diagnosis of CRS and the occupational cotton fibers exposure in a textile exhibition, the second also with CRS but without exposure to cotton and the third group without nasal symptoms. Biopsies average for subsequent immunohistochemical analysis turbinates and the presence of SED will be made. Results and conclusion: After analyzing samples of the mucosa of the selected patients will be possible to determine the variations found in this specific population, and thus we affirm the existence of greater B aureus enterotoxins that induce chronic rhinosinusitis, and you can then find a new avenue of approach of this pathology in this particular condition. (AU)