| Grant number: | 15/00544-6 |
| Support Opportunities: | Research Grants - Visiting Researcher Grant - International |
| Start date: | June 11, 2015 |
| End date: | June 24, 2015 |
| Field of knowledge: | Biological Sciences - Morphology - Cytology and Cell Biology |
| Principal Investigator: | Vanessa Morais Freitas |
| Grantee: | Vanessa Morais Freitas |
| Visiting researcher: | Gary S. Goldberg |
| Visiting researcher institution: | Rowan University, United States |
| Host Institution: | Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract
Communication between transformed and nontransformed cells is a critical process that regulates every stage of carcinogenesis. This reality is underscored by recent findings that mitochondrial DNA can transfer from normal host cells to xenograft cancer cells in order to help drive tumor cell metastasis. While the importance of stromal-tumor cell communication has been known for many decades, mechanisms that underlie these interactions have not been clearly elucidated. Exosomes and microvesicles have emerged as vehicles by which neighboring cells transfer information to control each other's behavior. Exosomes and microvesicles are small lipid encapsulated structures that travel outside of the cells and into neighboring cells, respectively. However, actual signals mediated by these dynamic structures have not been explored. We propose to elucidate fundamental processes by which exosomes and microvesicles form, as well as signals they transfer between transformed and nontransformed cells. Results from this colaboration could lead to novel methods to detect and treat a wide array of malignancies including oral, lung, ovary and breast cancer. (AU)
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