Extracellular vesicles: Role on inflammatory responses and potential uses in vaccination in cancer and infectious diseases

• Grant number: 15/06680-9
• Support Opportunities: Regular Research Grants - Publications - Scientific article
• Start date: May 01, 2015
• End date: October 31, 2015
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: Ana Claudia Trocoli Torrecilhas
• Grantee: Ana Claudia Trocoli Torrecilhas
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil

Abstract

Almost all cells and organisms release membrane structures containing proteins, lipids and nucleic acids called extracellular vesicles (EV), which have a wide range of functions concerning intercellular communication and signaling events. Recently, the characterization and understanding of their biological role has become a main research area due to their potential role in vaccination, as biomarkers antigens, early diagnostic tools, and therapeutic applications. Here, we will overview the recent advances and studies of EV shed by tumor cells, bacteria, parasites and fungi, focusing on their inflammatory role and their potential use in vaccination and diagnostic of cancer and infectious diseases. (AU)