Study of the thermal and chemical stability of new sunscreens

• Grant number: 14/22883-4
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2015
• End date: April 30, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Adelia Emilia de Almeida
• Grantee: Adelia Emilia de Almeida
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated researchers: Rosangela Gonçalves Peccinini ; Vera Lucia Borges Isaac

Abstract

Among the most used thermoanalytical techniques are Thermogravimetry (TG), Differential Thermal Analysis (DTA) and Differential Scanning Calorimetry (DSC). The thermoanalytical techniques have great importance in the pharmaceutical field due to the large variety of applications: study of purity, determination of glass transition temperatures and melting, study of polymorphism, determination of phase diagrams, study of the interaction between drug and excipients, determination of thermal stability. These techniques have been used both in the control of the raw material and the finished product as having potential use in the development and characterization of new products, evaluation of production processes of pharmaceuticals, medicines and cosmetics in general. Sunscreens, emerged with the aim to preventing skin cancer, sunburn and erythema associated with sun exposure and contribute to the reduction of photoaging. A product for sun protection should be stable to heat and sunlight enabling the protection of the individual for several hours without generating toxic photodegradation products. This work aims to study the thermal and chemical stability of two new series of synthesized sunscreens exhibit enhanced abilities to protect against UV radiation (UVA and UVB), obtained by molecular hybridization strategy among existing filters (avobenzone and cinnamates) and acid ferulic (natural product). (AU)