Evaluation of the regulatory role of genes associated with the via Wnt/b-catenin on the mechanisms of the DNA repair modulated by H. pylori

• Grant number: 14/11862-6
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2015
• End date: February 28, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Marcelo Lima Ribeiro
• Grantee: Marcelo Lima Ribeiro
• Host Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil
• Associated researchers: Ander Matheu Fernandez

Abstract

It is known that H. pylori infection triggers a pathological progression in the gastric mucosa which eventually culminates in the development of gastric cancer. Inevitably, the infection causes an inflammatory response in the host, which generates reactive oxygen species and nitrogen, which can cause protein alterations, damage to cell membranes and oxidation of the DNA molecule, which are known to be important steps in the development of gastric cancer . Furthermore, there is evidence in the literature and obtained by our research group, showing that H. pylori infection is closely associated with a reduction in the efficiency of DNA repair mechanisms, which would favor the accumulation of mutations and genomic instability favoring the genesis of gastric cancer. Some recent studies show the importance of the regulation of oncogenic Wnt/b-catenin and its downstream targets (mainly belonging SOX family) in various types of cancer. However, the association between genes and targets of Wnt/b-catenin in the DNA repair pathways are still poorly explored, especially in gastric carcinogenesis . Thus, we intend to evaluate the possible role of regulatory genes associated with the Wnt/b-catenin in the mechanisms of DNA repair modulated by H. pylori. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTOS, JULIANA C.; BRIANTI, MITSUE T.; ALMEIDA, VICTOR R.; ORTEGA, MANOELA M.; FISCHER, WOLFGANG; HAAS, RAINER; MATHEU, ANDER; RIBEIRO, MARCELO L.. Helicobacter pylori Infection Modulates the Expression of miRNAs Associated With DNA Mismatch Repair Pathway. Molecular Carcinogenesis, v. 56, n. 4, p. 1372-1379, APR 2017. (14/11862-6)

SANTOS, JULIANA C.; GAMBELONI, RAFAEL Z.; ROQUE, ALINE T.; OECK, SEBASTIAN; RIBEIRO, MARCELO L.. Epigenetic Mechanisms of ATM Activation after Helicobacter pylori Infection. American Journal of Pathology, v. 188, n. 2, p. 329-335, FEB 2018. (14/11862-6, 15/08775-7, 11/21710-0, 15/17768-4)

CARRASCO-GARCIA, ESTEFANIA; SANTOS, JULIANA C.; GARCIA, IDOIA; BRIANTI, MITSUE; GARCIA-PUGA, MIKEL; JR PEDRAZZOLI, JOSE; MATHEU, ANDER; RIBEIRO, MARCELO L.. Paradoxical role of SOX2 in gastric cancer. AMERICAN JOURNAL OF CANCER RESEARCH, v. 6, n. 4, p. 701-713, 2016. (14/11862-6, 11/21710-0)

SANTOS, JULIANA CARVALHO; CARRASCO-GARCIA, ESTEFANIA; GARCIA-PUGA, MIKEL; ALDAZ, PAULA; MONTES, MILAGROSA; FERNANDEZ-REYES, MARIA; DE OLIVEIRA, CAROLINE CANDIDA; LAWRIE, CHARLES H.; ARAUZO-BRAVO, MARCOS J.; RIBEIRO, MARCELO LIMA; et al. SOX9 Elevation Acts with Canonical WNT Signaling to Drive Gastric Cancer Progression. Cancer Research, v. 76, n. 22, p. 6735-6746, NOV 15 2016. (14/11862-6)