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Social and music performance anxiety: acute effects of oxytocin and Ayahuasca in voice, recognition of facial expressions,clinical and cognitive symptoms

Grant number: 15/02848-2
Support Opportunities:Regular Research Grants
Duration: July 01, 2015 - June 30, 2017
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal Investigator:Flávia de Lima Osório
Grantee:Flávia de Lima Osório
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated researchers:Jaime Eduardo Cecilio Hallak ; José Alexandre de Souza Crippa ; Lílian Neto Aguiar Ricz ; Marcos Hortes Nisihara Chagas ; Rafael Guimarães dos Santos


Although several medications are available for treating social anxiety disorder (SAD) and music performance anxiety (MPA), the treatment of these disorders still faces many difficulties, not only related to adverses reactions, that may reduce treatment adherence, but also because many of these drugs do not produce therapeutic effects in a significant proportion of patients, producing a high incidence of non-remission. Thus, the study of new pharmacological tools for handling these disorders is necessary. In this context, the objective of the present project is to evaluate the effects of oxytocin and ayahuasca in anxiety. For this purpose, three experimental studies will be conducted, with the following specific objectives: a) compare the behavioral, subjective and cognitive (social cognition) effects of a single ayahuasca dose between patients with social anxiety and healthy volunteers; b) assess the effects of anxiety in singing voice and the acute effects of oxytocin in the performance and voice pattern of musicians during a music performance simulation test, and c) evaluate social cognition in musicians by means of a facial emotion recognition task and assess the acute effects of oxytocin in relation to the level of music performance anxiety. According to previous results of studies conducted by our research group, it is expected that the substances under investigation may produce an acute anxiolytic effect in SAD and MPA, filling the need of substances with such a pharmacological profile and with fewer side-effects, in the clinical and performance level (specially regarding voice). (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SABINO, ALINI D. V.; CHAGAS, MARCOS HORTES N.; OSORIO, FLAVIA L.. Acute effects of oxytocin in music performance anxiety: a crossover, randomized, placebo-controlled trial. Psychopharmacology, v. 237, n. 6, . (15/02848-2)
VIANA SABINO, ALINI DANIELI; CHAGAS, MARCOS HORTES N.; OSORIO, FLAVIA L.. Effects of psychotropic drugs used in the treatment of anxiety disorders on the recognition of facial expressions of emotion: Critical analysis of literature. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 71, p. 802-809, . (15/02848-2)
OSORIO, FLAVIA L.; DE PAULA CASSIS, JULIANA M.; MACHADO DE SOUSA, JOAO P.; POLI-NETO, OMERO; MARTIN-SANTOS, ROCIO. Sex Hormones and Processing of Facial Expressions of Emotion: A Systematic Literature Review. FRONTIERS IN PSYCHOLOGY, v. 9, . (15/02848-2)
RAFAEL G. DOS SANTOS; FLÁVIA L. OSÓRIO; JOSÉ ALEXANDRE S. CRIPPA; JAIME E. C. HALLAK. Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies. Revista Brasileira de Psiquiatria, v. 38, n. 1, p. 65-72, . (15/02848-2)
DOS SANTOS, RAFAEL G.; SANCHES, RAFAEL FARIA; OSORIO, FLAVIA DE LIMA; HALLAK, JAIME E. C.. Long-term effects of ayahuasca in patients with recurrent depression: a 5-year qualitative follow-up. ARCHIVES OF CLINICAL PSYCHIATRY, v. 45, n. 1, p. 22-24, . (15/02848-2)
VIANA SABINO, ALINI DANIELI; CAMARGO, CRISTIELLI M.; CHAGAS, MARCOS HORTES N.; OSORIO, FLAVIA L.. Facial Recognition of Happiness Is Impaired in Musicians with High Music Performance Anxiety. FRONTIERS IN PSYCHIATRY, v. 9, . (15/02848-2)

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