Eicosanoids and the biology of gliomas: influence upon cell proliferation and migration and the response to chemotherapeutic drugs

• Grant number: 15/08777-0
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2015
• End date: July 31, 2017
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Principal Investigator: Alison Colquhoun
• Grantee: Alison Colquhoun
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Although there are genetic and proteomic studies of gliomas which allow the subdivision of tumours into several groups: mesenchymal, classical, neural, proneural and its G-CIMP subgroup, these data have not had the expected impact on the emergence of new and more effective targeted treatments for glioma patients. Previous studies in our group have identified altered profiles of bioactive lipids of the eicosanoid family between brain tumours of low and high degrees of malignancy. This project aims to expand the knowledge obtained from samples of primary tumours in order to identify which of the eicosanoids (prostaglandins, hydroxyoctadecadienoic, hydroxyeicosatetraenoic and hydroxyeicosapentaenoic acids) have real importance in glioma cell biology. The main objective of the project is to evaluate, in gliomas, the importance of eicosanoids for (i) the control of cell proliferation and cell death, (ii) the control of cell migration and invasion, and (iii) control of the multiple drug resistance phenomena. Based on our previous data and the scant literature on cyclooxygenases, lipoxygenases and multidrug resistance proteins, we believe that manipulation of the eicosanoid levels and their metabolism may have a positive influence on the response of gliomas to chemotherapeutic agents. We hope in this project to identify eicosanoids which will serve as novel targets for the development of effective adjuvant treatments. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA, MATTHEW THOMAS; GOMES, RENATA NASCIMENTO; PANAGOPOULOS, ALEXANDROS THEODOROS; DE ALMEIDA, FERNANDO GONSALVES; ESTEVES VEIGA, JOSE CARLOS; COLQUHOUN, ALISON. Opposing roles of PGD(2) in GSM. Prostaglandins & Other Lipid Mediators, v. 134, p. 66-76, JAN 2018. (15/08777-0)

COLQUHOUN, ALISON. Cell biology-metabolic crosstalk in glioma. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, v. 89, p. 171-181, AUG 2017. (15/08777-0)

PANAGOPOULOS, ALEXANDROS THEODOROS; GOMES, RENATA NASCIMENTO; ALMEIDA, FERNANDO GONCALVES; SOUZA, FELIPE DA COSTA; ESTEVES VEIGA, JOSE CARLOS; NICOLAOU, ANNA; COLQUHOUN, ALISON. The prostanoid pathway contains potential prognostic markers for glioblastoma. Prostaglandins & Other Lipid Mediators, v. 137, p. 52-62, JUL 2018. (15/08777-0)

SOUZA, FELIPE DA COSTA; FERREIRA, MATTHEW THOMAS; COLQUHOUN, ALISON. Influence of Lipoxygenase Inhibition on Glioblastoma Cell Biology. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, n. 21, NOV 2020. (15/08777-0)

PANAGOPOULOS, A.; SERACHI, F.; GOMES, R.; ROSSETTI, L.; VEIGA, J.; COLQUHOUN, A.. PROSTANOID METABOLISM AS A POTENTIAL TARGET FOR IMPROVED DRUG RESPONSE IN GLIOMAS. NEURO-ONCOLOGY, v. 19, p. 1-pg., 2017-05-01. (15/08777-0)

GOMES, RENATA NASCIMENTO; SOUZA, FELIPE DA COSTA; COLQUHOUN, ALISON. Eicosanoids and cancer. Clinics, v. 73, p. 10-pg., 2018-01-01. (15/08777-0)

GOMES, RENATA NASCIMENTO; SOUZA, FELIPE DA COSTA; COLQUHOUN, ALISON. Eicosanoids and cancer. Clinics, v. 73, n. 1, 2018. (15/08777-0)

FERREIRA, MATTHEW THOMAS; MIYAKE, JULIANO ANDREOLI; GOMES, RENATA NASCIMENTO; FEITOZA, FABIO; STEVANNATO, POLLYANA BULGARELLI; DA CUNHA, ANDREW SILVA; SERACHI, FERNANDA DE OLIVEIRA; PANAGOPOULOS, ALEXANDROS THEODOROS; COLQUHOUN, ALISON. Cyclooxygenase Inhibition Alters Proliferative, Migratory, and Invasive Properties of Human Glioblastoma Cells In Vitro. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 9, p. 23-pg., 2021-05-01. (15/08777-0)