A comprehensive study on osteoarthritis and osteochondrosis: characterization and biomarkers expression of the synovial membrane and synovial fluid cytokine profile

• Grant number: 14/13065-6
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2015
• End date: July 31, 2017
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Raquel Yvonne Arantes Baccarin
• Grantee: Raquel Yvonne Arantes Baccarin
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Bruno Cogliati ; Cristina de Oliveira Massoco Salles Gomes ; Fernanda Rodrigues Agreste ; Juliana Junqueira Moreira ; Luis Cláudio Lopes Correia da Silva ; Yara Maria Corrêa da Silva Michelacci

Abstract

In the equine species, osteochondrosis and osteoarthrosis are among the main articular disorders; they disturb articular cartilage homeostasis, and therefore lessen the likelihood of tissue repair. In this scenario, full knowledge of inflammatory and degenerative events affecting joint cartilage is vital for the development of an adequate therapeutic approach, to refrain diseases´ progression and to establish a correct prognosis. It is not known, so far, which form of treatment suits best a particular stage of a disease process during arthroscopy, as well as a more accurate prognosis regarding the athletic life of the animals. In face of these facts, the main goal of the present study is to harvest material from osteochondritic and osteoarthritic equine joints, namely synovial membrane and synovial fluid, to create a grading system for these articular disorders, in order to establish a pattern related to the disease severity, as well as references that can direct the best treatment outcome. Synovial membrane specimens will be obtained during arthroscopic surgery and will be evaluated macroscopically and histopatologically. Inflammatory biomarkers will also be studied in synovial membrane as well as in synovial fluid. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NEUENSCHWANDER, HENRIQUE M.; MOREIRA, JULIANA J.; VENDRUSCOLO, CYNTHIA P.; FULBER, JOICE; SEIDEL, SARAH R. T.; MICHELACCI, YARA M.; BACCARIN, RAQUEL Y. A.. Hyaluronic acid has chondroprotective and joint-preserving effects on LPS-induced synovitis in horses. Journal of Veterinary Science, v. 20, n. 6, NOV 2019. (10/16022-5, 14/13065-6, 13/07109-8)