Evaluation of pain and anesthetic efficacy after topical application of microneedles: a randomized clinical trial

• Grant number: 15/50004-8
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2015
• End date: June 30, 2018
• Field of knowledge: Health Sciences - Dentistry - Dental Clinics
• Agreement: Texas Tech University
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Michelle Franz Montan Braga Leite
• Grantee: Michelle Franz Montan Braga Leite
• Principal researcher abroad: Harvinder Singh Gill
• Institution abroad: Texas Tech University (TTU), United States
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
• Associated research grant: 12/06974-4 - Development, biocompatibility and permeation studies on gel formulations of poly-epsilon-caprolactone nanocapsules containing local anesthetics, AP.JP

Abstract

This current proposal aims to evaluate the feasibility of microneedles (MNs) as a drug delivery device at the oral mucosa to enable topical anesthesia. In Dentistry, topical anesthesia is performed prior to deep injection of local anesthesia. However, due (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTOS, STEPHANY DI CARLA; FAVARO-MOREIRA, NADIA CRISTINA; ABDALLA, HENRIQUE BALLASSIN; XAVIER AUGUSTO, GABRIELA GAMA; COSTA, YURI MARTINS; VOLPATO, MARIA CRISTINA; GROPPO, FRANCISCO CARLOS; GILL, HARVINDER SINGH; FRANZ-MONTAN, MICHELLE. A crossover clinical study to evaluate pain intensity from microneedle insertion in different parts of the oral cavity. International Journal of Pharmaceutics, v. 592, JAN 5 2021. (16/24057-0, 12/06974-4, 15/50004-8)