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Relationship between tumor budding and pathological variables and prognosis in liver metastases of colorectal cancer

Grant number: 15/06551-4
Support type:Regular Research Grants
Duration: August 01, 2015 - July 31, 2017
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Paulo Herman
Grantee:Paulo Herman
Home Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Assoc. researchers: Gilton Marques Fonseca

Abstract

Colorectal cancer (CRC) is one of the most frequent tumors and the most frequent cause of liver metastases. Surgical experience with colorectal cancer liver metastases (CRLM) has increased, leading to an overall 5-year survival up to 58%, showing that curative treatment is possible. There are many pathologic criteria with prognostic impact described for the primary tumor however, most of them have not been studied in CRLM as presence of tumor budding, when individual cells or groups of up to five detached cells beyond the tumor edge are observed. The presence of budding is considered a poor prognostic factor in CRC and an independent predictor of lymph node metastasis. Considering that the presence of tumor budding is related with epithelial mesenchymal transition and the wnt signaling pathway, there seems to be a possible correlation with the expression of E-cadherin and beta-catenin. The aim of this study is to evaluate the presence of tumor budding in patients with CRLM subjected to resection and its impact on prognosis. As secondary aims, other histopathologic factors as the presence of sinusoidal invasion, portal invasion and intra-hepatic lymphatic invasion will be evaluated. Moreover, we will try to correlate the presence of tumor budding and the expression of E-cadherin and beta-catenin. The results of this study may open perspectives to identify new histological criteria related to CRLM allowing a better prognostic stratification of patients and the identification of patterns of recurrence. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FONSECA, GILTON M.; DE MELLO, EVANDRO S.; FARAJ, SHEILA F.; KRUGER, JAIME A. P.; COELHO, FABRICIO F.; JEISMANN, VAGNER B.; LUPINACCI, RENATO M.; CECCONELLO, IVAN; ALVES, VENANCIO A. F.; PAWLIK, TIMOTHY M.; HERMAN, PAULO. Prognostic significance of poorly differentiated clusters and tumor budding in colorectal liver metastases. JOURNAL OF SURGICAL ONCOLOGY, v. 117, n. 7, p. 1364-1375, JUN 1 2018. Web of Science Citations: 7.
FONSECA, GILTON M.; HERMAN, PAULO; FARAJ, SHEILA F.; KRUGER, JAIME A. P.; COELHO, FABRICIO F.; JEISMANN, VAGNER B.; CECCONELLO, IVAN; ALVES, VENANCIO A. F.; PAWLIK, TIMOTHY M.; DE MELLO, EVANDRO S. Pathological factors and prognosis of resected liver metastases of colorectal carcinoma: implications and proposal for a pathological reporting protocol. Histopathology, v. 72, n. 3, p. 377-390, FEB 2018. Web of Science Citations: 7.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.