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Development of strategies for antitumor immunomodulation

Grant number: 15/01488-2
Support type:Regular Research Grants
Duration: September 01, 2015 - August 31, 2017
Field of knowledge:Biological Sciences - Immunology
Principal Investigator:Marcio Chaim Bajgelman
Grantee:Marcio Chaim Bajgelman
Home Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brasil). Campinas , SP, Brazil


Here we propose a new platform for antitumor immunotherapy based on the use of nanoparticles. These particles are engineered to interact with specific receptors on target cells in order to drive the tropism. In this proposal we plan to explore new nanoparticle formulations harboring different ligands to evaluate tropism selectivity and immunomodulatory properties. We also propose to generate in vitro assays to explore these combinations. The best nanoparticle candidates will be tested in vivo, using immunocompetent animals challenged with syngeneic tumors. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Novel cancer vaccine strategy is successfully tested  

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MANRIQUE-RINCON, ANDREA J.; BERALDO, CAMILA M.; TOSCARO, JESSICA M.; BAJGELMAN, MARCIO C. Exploring Synergy in Combinations of Tumor-Derived Vaccines That Harbor 4-1BBL, OX40L, and GM-CSF. FRONTIERS IN IMMUNOLOGY, v. 8, SEP 19 2017. Web of Science Citations: 1.

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