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Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease

Abstract

MICA-129 polymorphism affects the binding affinity of MICA molecules with the NKG2D receptor and influences effector cell function. The genotype met/met was associated with the severity of left ventricular systolic dysfunction(LVSD) in patients with chronic Chagas heart disease, while the val/val genotype was associated with the absence of LVSD. (AU)

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