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Computational EEG analysis for early Alzheimer's Disease diagnosis

Grant number: 15/09510-7
Support Opportunities:Regular Research Grants
Duration: October 01, 2015 - September 30, 2017
Field of knowledge:Engineering - Biomedical Engineering
Principal Investigator:Francisco José Fraga da Silva
Grantee:Francisco José Fraga da Silva
Host Institution: Centro de Engenharia, Modelagem e Ciências Sociais Aplicadas (CECS). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Associated researchers: Paulo Afonso Medeiros Kanda

Abstract

While the overall growth in life expectancy is extremely positive, the aging population has been followed around the world, for it also leads to some disturbing consequences, such as the increasing prevalence of neurodegenerative diseases. Among those, by far the one with highest incidence is Alzheimer's Disease (AD), which early detection is a pressing need, since it allows to start a treatment that can significantly retard disease progression. Therefore, it is extremely important the development of methods for supporting early AD diagnosis. Furthermore, when it comes to early diagnosis, mild cognitive impairment (MCI) has been shown as an important risk factor in the development of AD. Recent statistics show that about 50% of all people who reported MCI symptoms to a doctor will develop AD within four years, with 12% annual conversion rate in average. Over the past decade, quantitative electroencephalography (qEEG) has emerged as a reliable and cost-effective tool for the diagnosis of cortical disorders such as AD and MCI, due its wide availability, low-cost and use of non-invasive procedures, thus allowing health professionals perform serial examinations and monitor changes in neurological status. In this research project we intend to develop, improve and validate biomarkers based on computer analysis of the EEG signals for early diagnosis of both MCI and AD. Consequently, it is expected that from our effort on the search for effective EEG-based biomarkers may arise a computer application that integrates them all and thus significantly increases the accuracy, sensitivity and specificity on the important and urgent task of AD early detection. (AU)

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Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CASSANI, RAYMUNDO; FALK, TIAGO H.; FRAGA, FRANCISCO J.; CECCHI, MARCO; MOORE, DENNIS K.; ANGHINAH, RENATO. Towards automated electroencephalography-based Alzheimer's disease diagnosis using portable low-density devices. Biomedical Signal Processing and Control, v. 33, p. 261-271, . (15/09510-7)
FRAGA, FRANCISCO J.; MAMANI, GODOFREDO QUISPE; JOHNS, ERIN; TAVARES, GUILHERME; FALK, TIAGO H.; PHILLIPS, NATALIE A.. Early diagnosis of mild cognitive impairment and Alzheimer's with event-related potentials and event-related desynchronization in N-back working memory tasks. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, v. 164, p. 1-13, . (17/15243-7, 15/09510-7)
JÉSSICA NATULINE IANOF; FRANCISCO JOSÉ FRAGA; LEONARDO ALVES FERREIRA; RENATO TEODORO RAMOS; JOSÉ LUIZ CARLOS DEMARIO; REGINA BARATHO; LUÍS FERNANDO HINDI BASILE; RICARDO NITRINI; RENATO ANGHINAH. ANÁLISE COMPARATIVA DO ELETROENCEFALOGRAMA EM PACIENTES COM DOENÇA DE ALZHEIMER, LESÃO AXONAL DIFUSA E CONTROLES SAUDÁVEIS: E ANÁLISE LORETA. Dement. Neuropsychol., v. 11, n. 2, p. 176-185, . (15/09510-7)
GRILO JR, MARCELO; SANTOS, ELIANA; MORAES, CAROLINE; MONDEJAR, ALICE; ASCENCAO, PAULO; ARAUJO, LUCIANO; NEVES, ALINE; FRAGA, FRANCISCO; IEEE. Limbs Movement and Motor Imagery: an EEG Study. 2019 E-HEALTH AND BIOENGINEERING CONFERENCE (EHB), v. N/A, p. 4-pg., . (17/15243-7, 15/09510-7)
SAN-MARTIN, RODRIGO; CASTRO, LEONARDO ANDRADE; MENEZES, PAULO ROSSI; FRAGA, FRANCISCO JOSE; SIMOES, PRISCYLA WALESKA; SALUM, CRISTIANE. Meta-Analysis of Sensorimotor Gating Deficits in Patients With Schizophrenia Evaluated by Prepulse Inhibition Test. SCHIZOPHRENIA BULLETIN, v. 46, n. 6, p. 1482-1497, . (15/09510-7)
ASCENCAO, PAULO V.; SANTOS, ELIANA M.; LACERDA, LUCIANO H.; FRAGA, FRANCISCO J.; IEEE. Evaluation of Performance Metrics for Users of Brain Computer Interfaces during Motor Imagery. 2019 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN AND CYBERNETICS (SMC), v. N/A, p. 6-pg., . (15/09510-7)
SAN-MARTIN, RODRIGO; JOHNS, ERIN; MAMANI, GODOFREDO QUISPE; TAVARES, GUILHERME; PHILLIPS, NATALIE A.; FRAGA, FRANCISCO J.. A method for diagnosis support of mild cognitive impairment through EEG rhythms source location during working memory tasks. Biomedical Signal Processing and Control, v. 66, . (17/15243-7, 15/09510-7)
TAVARES, GUILHERME; SAN-MARTIN, RODRIGO; IANOF, JESSICA N.; ANGHINAH, RENATO; FRAGA, FRANCISCO J.; IEEE. Improvement in the automatic classification of Alzheimer's disease using EEG after feature selection. 2019 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN AND CYBERNETICS (SMC), v. N/A, p. 6-pg., . (17/15243-7, 15/09510-7)
DOS SANTOS, ELIANA M. M.; SAN-MARTIN, RODRIGO; FRAGA, FRANCISCO J. J.. Comparison of subject-independent and subject-specific EEG-based BCI using LDA and SVM classifiers. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, v. 61, n. 3, p. 11-pg., . (17/15243-7, 15/09510-7)
MAMANI, GODOFREDO QUISPE; FRAGA, FRANCISCO J.; TAVARES, GUILHERME; JOHNS, ERIN; PHILLIPS, NATALIE D.; IEEE. EEG-Based Biomarkers on Working Memory Tasks for Early Diagnosis of Alzheimer's Disease and Mild Cognitive Impairment. 2017 IEEE-NIH HEALTHCARE INNOVATIONS AND POINT OF CARE TECHNOLOGIES (HI-POCT), v. N/A, p. 4-pg., . (15/09510-7)
KANDA, PAULO A. M.; OLIVEIRA, ELIEZYER F.; FRAGA, FRANCISCO J.. EEG epochs with less alpha rhythm improve discrimination of mild Alzheimer's. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, v. 138, p. 13-22, . (15/09510-7)
FRAGA, FRANCISCO J.; FERREIRA, LEONARDO A.; FALK, TIAGO H.; JOHNS, ERIN; PHILLIPS, NATALIE D.; IEEE. EVENT-RELATED SYNCHRONISATION RESPONSES TO N-BACK MEMORY TASKS DISCRIMINATE BETWEEN HEALTHY AGEING, MILD COGNITIVE IMPAIRMENT, AND MILD ALZHEIMER'S DISEASE. 2017 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH AND SIGNAL PROCESSING (ICASSP), v. N/A, p. 5-pg., . (15/09510-7)
SANTOS, ELIANA M.; SAN-MARTIN, RODRIGO; FRAGA, FRANCISCO J.; IEEE. Comparison of LORETA and CSP for Brain-Computer Interface Applications. 2021 18TH INTERNATIONAL MULTI-CONFERENCE ON SYSTEMS, SIGNALS & DEVICES (SSD), v. N/A, p. 6-pg., . (17/15243-7, 15/09510-7)
PEDROSO, RENATA VALLE; CANCELA, JOSE MARIA; AYAN, CARLOS; STEIN, ANGELICA MIKI; FUZARO, GILSON; COSTA, JOSE LUIZ RIANI; FRAGA, FRANCISCO J.; SANTOS-GALDUROZ, RUTH FERREIRA. Effects of Physical Exercise on the P300 of Elderly With Alzheimer's Disease. JOURNAL OF PHYSICAL ACTIVITY & HEALTH, v. 15, n. 6, p. 403-410, . (15/09510-7)

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