| Grant number: | 15/50347-2 |
| Support Opportunities: | Regular Research Grants |
| Start date: | October 01, 2015 |
| End date: | March 31, 2018 |
| Field of knowledge: | Biological Sciences - Biophysics - Molecular Biophysics |
| Agreement: | BBSRC, UKRI - FAPPA |
| Principal Investigator: | Ana Paula Ulian de Araujo |
| Grantee: | Ana Paula Ulian de Araujo |
| Principal researcher abroad: | Bonnie Ann Wallace |
| Institution abroad: | University of London , England |
| Host Institution: | Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil |
| City of the host institution: | São Carlos |
Abstract
This project would use novel developments for spectroscopic characterization of these AMP in liposomes, lipid films and lipid monolayers to establish the mechanism of action and optimize the design of novel related peptides as bacteriocins. The project will also focus on the identification and characterisation of new hyper-stable enzymes isolated from petrochemical sources. Extremophiles isolated from hot oilfield waters produce a range pf enzymes that exhibit both thermostability and stability in non- aqueous solvents, that give them potential for use in industrial applications where their unique properties are compatible with bioprocessing and biomodification requirements. This project will examine the thermal stability and environmental stability factors associated with enzymes from extremophile isolates using a range of novel spectroscopic methods, including SRCD and fluorescence. The functional enzymatic properties would be correlated with structural features, in particular in organic, lipophilic and other non-aqueous milleux. (AU)
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