Surface modification of stainless steel, pure and alloy titanium for biofilm prevention: comparative study between surface engineering and the use of antibiotics

• Grant number: 15/20438-6
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2016
• End date: January 31, 2018
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: William de Melo Silva
• Grantee: William de Melo Silva
• Host Institution: Instituto de Biotecnologia (IBTEC). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Every day occur microorganism film formation on to surfaces in many situations, for example in hydraulic systems as sinks and pipes, on surgical instruments, and in addition, in areas of food and water reservoirs. That film has the ability to strongly adhere onto a surface, thus forming the so-called "biofilm". The formation of a protective layer comprising a polymeric extracellular substance is a peculiar feature of biofilms, giving the organism present in the biofilm resistance to external agents harmful its natural maintenance and reproduction. A more specific knowledge of biofilms is required and has direct relevance for public health, in view of their role in disease transmission. The relevant aspects are: adhesiveness, three-dimensional microstructure, genetic material of cells which constitute a biofilm and antibiotic activity. This project is expected to understand, through experimental tests in laboratory, all these aspects. Although, it is widely known that humidity and temperature influence the reproduction of each organism that forms biofilms, one realizes that they are not unique and require scientific research. This investigative study will enable a better understanding of the most common proliferation sites of related diseases, the prophylaxis and treatment strategies more and less efficient, and what is necessary to design a surface capable of reducing or preventing biofilm formation. Thus, the objective of this project is the publication of high quality scientific papers with information to collaborate with biofilm control strategies, leading to a reduction in transmission of disease, and thereby improve the quality of human life. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, WILLIAM DE MELO; RIBEIRO, CAMILA AMORIM; MARQUES, CLEITON SILVA; TABATA, AMERICO SHEITIRO; SAEKI, MARGARIDA JURI; MEDEIROS, LEONARDO IUSUTI; DE OLIVEIRA, DEILSON ELGUI. Fibroblast and pre-osteoblast cell adhesive behavior on titanium alloy coated with diamond film. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 20, n. 2, p. 284-290, 2017. (15/20438-6)

SILVA, WILLIAM DE MELO; MARTINS, PAULO SERGIO; DE CARVALHO, VAGNER EUSTIQUIO; DA CRUZ, NILSON CRISTINO; CLAUDINO, ENZO; GONCALVES CARNEIRO, JOSE RUBENS. Improving Precision in Aluminum Alloy Machining Due to the Application of Diamond-Like Carbon Thin Film. JOURNAL OF TRIBOLOGY-TRANSACTIONS OF THE ASME, v. 143, n. 7, JUL 1 2021. (15/20438-6)