The role of ECA2/Ang 1-7/Mas axis in the prevention of obesity and insulin resistance by physical training

• Grant number: 15/04948-4
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2016
• End date: January 31, 2018
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Fabiana de Sant'Anna Evangelista
• Grantee: Fabiana de Sant'Anna Evangelista
• Host Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The association between obesity, insulin resistance and type 2 diabetes (DM2) has been widely demonstrated in the literature, and a key factor that involves the participation of various organs in the development and progression of metabolic diseases is the collective loss in the ability to handle excess lipids associated with reduced tissue oxidative capacity. The understanding of the cellular mechanisms of metabolic diseases can identify new therapeutic targets, and in this context, the investigation of the renin angiotensin system (RAS), the axis ACE / Ang II / AT1 and ACE2 / Ang 1-7 / Mas seems be promising. While the hyperactivity of ACE / Ang II / AT1 is deleterious for the energy metabolism, induces obesity, insulin resistance in peripheral tissues and DM2, the activation of the ACE2 / Ang 1-7 / Mas axis could alleviate the clinical manifestations of metabolic diseases. Aerobic physical training has been widely recommended for the prevention and treatment of metabolic diseases due to the adaptations in metabolically active tissues that reflect in the improvement of oxidative metabolism, reduction in deposits of lipids and increase in insulin sensitivity. Part of the benefits of physical training responses may be mediated by a reduction in ACE / Ang II / AT1 axis, and although the increase in ACE2 / Ang 1-7 / Mas axis can also mediate the effects of physical training, the data to date have been only observed in cardiovascular diseases. However, a large knowledge gap exists about the role of ACE2 / Ang 1-7 / Mas in the prevention of metabolic diseases. Thus, this project aims to investigate whether the protective effect of exercise training against obesity and insulin resistance is mediated by the activation of ACE2 / Ang 1-7 / Mas axis in skeletal muscle and white adipose tissue. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AMERICO, ANNA LAURA V.; MULLER, CYNTHIA R.; VECCHIATTO, BRUNO; MARTUCCI, LUIZ FELIPE; FONSECA-ALANIZ, MIRIAM H.; EVANGELISTA, FABIANA S.. Aerobic exercise training prevents obesity and insulin resistance independent of the renin angiotensin system modulation in the subcutaneous white adipose tissue. PLoS One, v. 14, n. 4, APR 25 2019. (15/04948-4, 16/23783-9)

MULLER, CYNTHIA RODRIGUES; VIACAVA AMERICO, ANNA LAURA; FIORINO, PATRICIA; EVANGELISTA, FABIANA SANT'ANNA. Aerobic exercise training prevents renal damage in insulin resistance mice. FASEB JOURNAL, v. 31, p. 1-pg., 2017-04-01. (15/04948-4)

MULLER, CYNTHIA RODRIGUES; AMERICO, ANNA LAURA VIACAVA; PEREIRA, RENATA OLIVEIRA; MATSUMOTO, ALICE JACKELINE; FIORINO, PATRICIA; EVANGELISTA, FABIANA SANT'ANNA. Aerobic exercise training prevents renal lipotoxicity associated with insulin resistance in mice. FASEB JOURNAL, v. 32, n. 1, p. 2-pg., 2018-04-01. (15/04948-4)

AMERICO, ANNA LAURA VIACAVA; MULLER, CYNTHIA RODRIGUES; FONSECA-ALANIZ, MIRIAM HELENA; EVANGELISTA, FABIANA SANT'ANNA. The role of ACE2/Ang 1-7/Mas axis in the white adipose tissue for the prevention of obesity and insulin resistance through aerobic exercise training. FASEB JOURNAL, v. 32, n. 1, p. 2-pg., 2018-04-01. (16/23783-9, 15/04948-4)

VECCHIATTO, BRUNO; MARTUCCI, LUIZ FELIPE; AMERICO, ANNA LAURA VIACAVA; MULLER, CYNTHIA RODRIGUES; EVANGELISTA, FABIANA SANT'ANNA. The prevention of cardiometabolic risk factors is associated with the improvement in aerobic capacity. FASEB JOURNAL, v. 32, n. 1, p. 2-pg., 2018-04-01. (16/20659-5, 15/04948-4)

MULLER, C. R.; AMERICO, V, A. L.; FIORINO, P.; EVANGELISTA, F. S.. Aerobic exercise training prevents kidney lipid deposition in mice fed a cafeteria diet. Life Sciences, v. 211, p. 140-146, OCT 15 2018. (15/04948-4)

VECCHIATTO, BRUNO; DA SILVA, RAFAEL C.; HIGA, TALITA S.; MULLER, CYNTHIA R.; AMERICO, V, ANNA LAURA; FORTUNATO-LIMA, VANESSA C.; FERREIRA, MARILIA M.; MARTUCCI, LUIZ FELIPE; FONSECA-ALANIZ, MIRIAM H.; EVANGELISTA, FABIANA S.. Oxidative phenotype induced by aerobic physical training prevents the obesity-linked insulin resistance without changes in gastrocnemius muscle ACE2-Angiotensin(1-7)-Mas axis. DIABETOLOGY & METABOLIC SYNDROME, v. 13, n. 1, JUL 6 2021. (16/20659-5, 15/04948-4)

VIACAVA AMERICO, ANNA LAURA; MULLER, CYNTHIA RODRIGUES; FONSECA-ALANIZ, MIRIAM HELENA; EVANGELISTA, FABIANA SANT'ANNA. Differentiated contribution of fat pads to the prevention of insulin resistance through aerobic exercise training. FASEB JOURNAL, v. 31, p. 1-pg., 2017-04-01. (15/04948-4)

EVANGELISTA, FABIANA; VECCHIATTO, BRUNO; AMERICO, ANNA; MARTUCCI, LUIZ; FERREIRA, MARILIA; MULLER, CYNTHIA. Aerobic Exercise Training Prevents Obesity and Insulin Resistance Independent of Changes in the Skeletal Muscle ACE2/Ang 1-7/Mas Axis. FASEB JOURNAL, v. 34, p. 2-pg., 2020-04-01. (16/23783-9, 16/20659-5, 15/04948-4)