Plasma from preeclamptic patients induces the expression of the antiangiogenic miR-195-5p in endothelial cells

• Grant number: 15/24884-0
• Support Opportunities: Regular Research Grants - Publications - Scientific article
• Start date: March 01, 2016
• End date: August 31, 2016
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Valeria Cristina Sandrim
• Grantee: Valeria Cristina Sandrim
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Endothelial cells incubated with plasma from preeclamptic pregnant show increased miR-195-5p expression, which may contribute to decreased expression of VEGFA(gene and protein) and increased antiangiogenic status in preeclampsia. Therefore, this miR may be an important target in preeclampsia. (AU)