The natural history of lacrimal and salivary gland dysfunction in Sjögren's syndrome

• Grant number: 14/23211-0
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2016
• End date: January 31, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Eduardo Melani Rocha
• Grantee: Eduardo Melani Rocha
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Denny Marcos Garcia ; Jorge Esquiche León ; Paulo Louzada Junior

Abstract

Tears and saliva play multiple roles in health. These secretions moisten, lubricate, nourish and protect the ocualr surface aond mouth, respectively. The tears helps in vision and saliva in speech and swallowing food . Moreover, both control microbial populations and promote the renovation and repair of tissues. Therefore, the lacrimal and salivary dysfunction, or a combination of both may affect the visual , oral and systemic health, and a quality of life. Such dysfunctions are the result of numerous clinical conditions whose pathophysiological mechanisms are still poorly understood and the limited therapeutic possibilities.Sjögren's syndrome ( SS ) is an autoimmune exocrinopathy that primarily affects the lacrimal and salivary glands . Although the disease was described in 1933, a series of unanswered questions persist, concerning the causes ,the progression rate of the secretory dysfunction , ocular, oral and systemic complications associated with xerostomia in autoimmune and non- autoimmune disorders, dysregulation of B lymphocytes and parameters of worsening or improvment. Moreover, more accurate estimates of the incidence of the development of lymphoma and other co - morbidities in this syndrome are needed.The general purposes of this study are multidisciplinary, comparative of clinical, histologic and molecular parameters monitoring of patients with SS and non SS regarding to changes on the lacrimal glands, ocular surface , salivary glands , arthropathy , endocrine abnormalities and other manifestations, to document the natural history and identify the causes and the patterns of SS progress. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MO, YING-QIAN; NAKAMURA, HIROYUKI; TANAKA, TSUTOMU; ODANI, TOSHIO; PEREZ, PAOLA; JI, YOUNGMI; FRENCH, BENJAMIN N.; PRANZATELLI, THOMAS J. F.; MICHAEL, DREW G.; YIN, HONGEN; et al. Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjogren's syndrome. Journal of Clinical Investigation, v. 132, n. 6, p. 15-pg., 2022-03-15. (14/22451-7, 14/23211-0)

GARCIA, DENNY MARCOS; DE OLIVEIRA, FABIOLA REIS; MODULO, CAROLINA MARIA; FAUSTINO, JACQUELINE; BARBOSA, AMANDA PIRES; ALVES, MONICA; ROCHA, EDUARDO MELANI. Is Sjogren's syndrome dry eye similar to dry eye caused by other etiologies? Discriminating different diseases by dry eye tests. PLoS One, v. 13, n. 12, DEC 3 2018. (14/23211-0, 14/22451-7)

FAUSTINO-BARROS, JACQUELINE FERREIRA; SANT'ANA, ARIANE MIRELA SARANZO; DIAS, LARA CRISTINA; MURASHIMA, ADRIANA DE ANDRADE BATISTA; DA SILVA, LILIAN ESLAINE COSTA MENDES; FANTUCCI, MARINA ZILIO; GARCIA, DENNY MARCOS; ROCHA, EDUARDO MELANI. Distinct Inflammatory and Oxidative Effects of Diabetes Mellitus and Hypothyroidism in the Lacrimal Functional Unit. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 8, p. 11-pg., 2023-04-01. (14/23211-0, 14/22451-7)

TANAKA, TSUTOMU; WARNER, BLAKE M.; ODANI, TOSHIO; JI, YOUNGMI; MO, YING-QIAN; NAKAMURA, HIROYUKI; JANG, SHYH-ING; YIN, HONGEN; MICHAEL, DREW G.; HIRATA, NORIYUKI; et al. LAMP3 induces apoptosis and autoantigen release in Sjogren's syndrome patients. SCIENTIFIC REPORTS, v. 10, n. 1, p. 17-pg., 2020-09-16. (14/22451-7, 14/23211-0)

AMANDA PIRES BARBOSA; FABÍOLA REIS DE OLIVEIRA; FLAVIO JAIME DA ROCHA; VALDAIR FRANCISCO MUGLIA; EDUARDO MELANI ROCHA. Lacrimal gland atrophy and dry eye related to isotretinoin, androgen, and prolactin: differential diagnosis for Sjogren's syndrome. Arquivos Brasileiros de Oftalmologia, v. 84, n. 1, p. 78-82, Jan. 2021. (14/23211-0, 14/22451-7)

JACQUELINE FERREIRA FAUSTINO BARROS; ARIANE MIRELA SARANZO SANT'ANA; LARA CRISTINA DIAS; ADRIANA DE ANDRADE BATISTA MURASHIMA; LILIAN ESLAINE COSTA MENDES DA SILVA; MARINA ZILIO FANTUCCI; EDUARDO MELANI ROCHA. Comparação dos efeitos da denervação da córnea e da glândula lacrimal na unidade funcional lacrimal de ratos. Arquivos Brasileiros de Oftalmologia, v. 85, n. 1, p. 59-67, 2021-09-10. (14/22451-7, 14/23211-0)

NAKAMURA, HIROYUKI; TANAKA, TSUTOMU; JI, YOUNGMI; ZHENG, CHANGYU; AFIONE, SANDRA A. A.; WARNER, BLAKE M. M.; OLIVEIRA, FABIOLA REIS; MOTTA, ANA CAROLINA F.; ROCHA, EDUARDO M. M.; NOGUCHI, MASAYUKI; et al. Salivary gland LAMP3 mRNA expression is a possible predictive marker in the response to hydroxychloroquine in Sjogren's disease. PLoS One, v. 18, n. 2, p. 14-pg., 2023-02-23. (14/23211-0)