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Light/dark regulation of bone marrow stem cell production of blood and immune cells during homeostasis and inflammation

Grant number: 15/50166-8
Support Opportunities:Regular Research Grants
Duration: February 01, 2016 - January 31, 2019
Field of knowledge:Biological Sciences - Physiology - General Physiology
Convênio/Acordo: Weizmann Institute of Science
Principal Investigator:Regina Pekelmann Markus
Grantee:Regina Pekelmann Markus
Principal researcher abroad: Tsvee Lapidot
Institution abroad: Weizmann Institute of Science, Israel
Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Our collaborative project aims at understanding how light/dark dependent signals regulate physiologic immune-cell generation and host-defense as part of homeostasis and in response to inflammatory insult. Identificating regulatory mechanisms and key molecules will provide new targets for improving clinical procedures such as stem cell transplantation and immunotherapy. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOLAN, KARIN; KUMARI, ANJU; KOLLET, ORIT; KHATIB-MASSALHA, EMAN; SUBRAMANIAM, MOHANA DEVI; FERREIRA, ZULMA S.; AVEMARIA, FRANCESCA; RZESZOTEK, SYLWIA; GARCIA-GARCIA, ANDRES; XIE, STEPHANIE; et al. Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance. CELL STEM CELL, v. 23, n. 4, p. 572+, . (15/50166-8)

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