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Functional detailing of CD99 role in astrocytomas

Grant number: 15/03614-5
Support type:Regular Research Grants
Duration: March 01, 2016 - September 30, 2018
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Sueli Mieko Oba Shinjo
Grantee:Sueli Mieko Oba Shinjo
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers: Roseli da Silva Soares ; Suely Kazue Nagahashi Marie

Abstract

Astrocytomas are among the most common tumors of the central nervous system and are classified according to the degree of malignancy from I to IV, considering histological and genetic alterations of the tumor. The grade IV or glioblastoma (GBM) is the most frequent and malignant and standard treatment consists on tumor surgical resection followed by radiotherapy and chemotherapy with temozolomide. Despite this aggressive treatment, the median survival of patients with GBM is around one year. In order to increase patient survival, researchers try to combine the standard therapy with other biological therapies. To this end, several studies have been developed searching for membrane proteins expressed in different tumor types, including GBM, which could serve as therapeutic targets. In this context, CD99 is a protein expressed on the membrane of hematopoietic cells and other cell types and plays a role in differentiation, adhesion and migration of T and B lymphocytes. CD99 has also been described in various types of tumors, including sarcoma and GBM. Our laboratory has shown high levels of mRNA and protein in GBM tissue samples and cell lines. A detailed study of the CD99 role will be performed by analyzing the transcriptome of GBM cell lines (A172 and U87MG) knocked out for CD99 expression in order to identify signaling pathways modulated by CD99. The transcriptome analysis will direct functional studies to be conducted to substantiate the findings. Additionally, the tumorigenic capacity of knocked cell lines will be evaluated in vivo. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LAURENTINO, TALITA DE S.; SOARES, ROSELI DA S.; LERARIO, ANTONIO M.; MARIE, SUELY K. N.; OBA-SHINJO, SUELI M. LOXL3 Silencing Affected Cell Adhesion and Invasion in U87MG Glioma Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 15 AUG 2021. Web of Science Citations: 0.
MAGALHAES, TACIANI DE ALMEIDA; BORGES, KLEITON SILVA; DE SOUSA, GRAZIELLA RIBEIRO; BRANDALISE, SILVIA REGINA; SEIDINGER, ANA LUIZA; SCRIDELI, CARLOS ALBERTO; OBA-SHINJO, SUELI MIEKO; YUNES, JOSE ANDRES; TONE, LUIZ GONZAGA. The TP53 p.R337H mutation is uncommon in a Brazilian cohort of pediatric patients diagnosed with ependymoma. NEUROLOGICAL SCIENCES, v. 41, n. 3, p. 691-694, MAR 2020. Web of Science Citations: 0.
CARDOSO, LAIS C.; SOARES, ROSELI DA S.; LAURENTINO, TALITA DE S.; LERARIO, ANTONIO M.; MARIE, SUELY K. N.; OBA-SHINJO, SUELI MIEKO. CD99 Expression in Glioblastoma Molecular Subtypes and Role in Migration and Invasion. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 5 MAR 1 2019. Web of Science Citations: 0.
FERNANDA DE OLIVEIRA SERACHI; SUELY KAZUE NAGAHASHI MARIE; SUELI MIEKO OBA-SHINJO. Relevant coexpression of STMN1, MELK and FOXM1 in glioblastoma and review of the impact of STMN1 in cancer biology. MedicalExpress (São Paulo, online), v. 4, n. 5, p. -, Out. 2017.

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