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Analysis polymorphisms in receivers and route metabolic estrogen in women postmenopausal women with tendinopathy the rear tibial

Grant number: 15/19635-1
Support type:Regular Research Grants
Duration: March 01, 2016 - February 28, 2018
Field of knowledge:Health Sciences - Medicine - Surgery
Principal researcher:Alexandre Leme Godoy dos Santos
Grantee:Alexandre Leme Godoy dos Santos
Home Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Assoc. researchers: Alejandro Agustin Carri Zoboli ; Edmund Chada Baracat ; José Maria Soares Junior ; Maria Cristina Leme Godoy dos Santos ; Pedro Augusto Pontin ; Tulio Diniz Fernandes

Abstract

Posterior tibial tendon tendinopathy (PTT) is the main cause of acquired flatfoot in adults. These disease is more common in females, patients with comorbidities such as obesity, diabetes mellitus, hypertension and rheumatologic diseases, and the peak incidence occurs in the sixth decade of life. Although some risk factors are related to the development of PTT, many patients develop PTT in their absence, suggesting an influence of intrinsic molecular factors associated with the disease process. Genes related to hormone metabolism, when acting in combination with behavioral and endogenous factors could be responsible for most cases of PTT. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PONTIN, P. A.; NOGARA, P. R. B.; FONSECA, F. C. P.; NETTO, C. CESAR; CARVALHO, K. C.; SOARES JUNIOR, J. M.; BARACAT, E. C.; FERNANDES, T. D.; MAFFULLI, N.; SANTOS, M. C. L.; GODOY-SANTOS, A. L. ER PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study. JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, v. 13, DEC 11 2018. Web of Science Citations: 0.

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