Analysis polymorphisms in receivers and route metabolic estrogen in women postmenopausal women with tendinopathy the rear tibial

• Grant number: 15/19635-1
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2016
• End date: February 28, 2018
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Alexandre Leme Godoy dos Santos
• Grantee: Alexandre Leme Godoy dos Santos
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Alejandro Agustin Carri Zoboli ; Edmund Chada Baracat ; José Maria Soares Junior ; Maria Cristina Leme Godoy dos Santos ; Pedro Augusto Pontin ; Tulio Diniz Fernandes

Abstract

Posterior tibial tendon tendinopathy (PTT) is the main cause of acquired flatfoot in adults. This disease is more common in females, patients with comorbidities such as obesity, diabetes mellitus, hypertension and rheumatologic diseases, and the peak incidence occurs in the sixth decade of life. Although some risk factors are related to the development of PTT, many patients develop PTT in their absence, suggesting an influence of intrinsic molecular factors associated with the disease process. Genes related to hormone metabolism, when acting in combination with behavioral and endogenous factors, could be responsible for most cases of PTT. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PONTIN, P. A.; NOGARA, P. R. B.; FONSECA, F. C. P.; NETTO, C. CESAR; CARVALHO, K. C.; SOARES JUNIOR, J. M.; BARACAT, E. C.; FERNANDES, T. D.; MAFFULLI, N.; SANTOS, M. C. L.; et al. ER PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study. JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, v. 13, DEC 11 2018. (15/19635-1)