Functional activity of mononuclear cells of colostrum of mothers with overweight and obesity and the role of immunomodulators agents: adiponectin, leptin and melatonin.

• Grant number: 15/19922-0
• Support Opportunities: Regular Research Grants
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Luiz Carlos de Abreu
• Grantee: Luiz Carlos de Abreu
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Adenilda Cristina Honorio França ; Eduardo Luzía França

Abstract

Obesity is an important public health problem. Need special attention in critical phases as it is in pregnancy and infancy. There is evidence that maternal obesity promotes changes in the newborn metabolism that can lead to increased risk of the developing obesity and other diseases during adulthood. The breast milk is an important modulator of the metabolism and the child's immune system. Human milk has constituents in their composition with ability to influence the regulation of energy metabolism, such as adiponectin, leptin and melatonin. These bioactive substances also have activities on the functioning of immune cells. Obesity causes changes in the breast milk constituents, however it is not known how much obesity affects the action of mononuclear cells that are transmitted to the infant via colostrum. Therefore the objective of this study is evaluating the mechanisms involved in the activation of leukocytes of overweight and obesity women and the modulatory role of adiponectin, leptin and melatonin. The colostrum mononuclear cells will be separated by concentration gradient and are used in assays phagocytosis and oxidative burst, intracellular calcium and apoptosis. Will be added adiponectin, leptin and melatonin stimuli and analyzes will be performed by flow cytometry. Thus expected to generate specific knowledge about the influence of overweight in the function of mononuclear cells from human colostrum, which contributes to better care of maternal and child health. This is still a subject little described in the literature and can cause repercussions on the scene of Public Health, especially in the field of future obesity. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BRAGA ROCHA, ELIDA MARA; DE ABREU, LUIZ CARLOS; LOPES, AMANDA FORSTER; LEONE, CLAUDIO; VIEIRA, PATRICIA DORE; PINHEIRO BEZERRA, ITALLA MARIA; SZARFARC, SOPHIA CORNBLUTH. Relation of Food Insecurity and Hemoglobin Level in Preschool Aged Children. ANEMIA, 2018. (15/19922-0)

DE QUENTAL, OCILMA B.; FRANCA, EDUARDO L.; HONORIO-FRANCA, ADENILDA C.; MORAIS, TASSIANE C.; DABOIN, BLANCA E. G.; BEZERRA, ITALLA M. P.; KOMNINAKIS, V, SHIRLEY; DE ABREU, LUIZ C.. Zika Virus Alters the Viscosity and Cytokines Profile in Human Colostrum. JOURNAL OF IMMUNOLOGY RESEARCH, v. 2019, NOV 15 2019. (15/01051-3, 15/19922-0)

MORAIS, TASSIANE C.; HONORIO-FRANCA, ADENILDA C.; FUJIMORI, MAHMI; DE QUENTAL, OCILMA B.; PESSOA, RAFAEL S.; FRANCA, EDUARDO L.; DE ABREU, LUIZ C.. Melatonin Action on the Activity of Phagocytes from the Colostrum of Obese Women. MEDICINA-LITHUANIA, v. 55, n. 10, OCT 2019. (15/01051-3, 15/19922-0)

SILVA, ROMEU P. M.; BARROS, CRISTIANO L. M.; MENDES, THIAGO T.; GARCIA, EMERSON S.; VALENTI, VITOR E.; DE ABREU, LUIZ CARLOS; GARNER, DAVID M.; ESPINDOLA, FOUED SALMEN; PENHA-SILVA, NILSON. The influence of a hot environment on physiological stress responses in exercise until exhaustion (vol 14, e0209510, 2019). PLoS One, v. 14, n. 3, p. 1-pg., 2019-03-25. (15/19922-0)

MORAIS, TASSIANE C.; DE ABREU, LUIZ C.; DE QUENTAL, OCILMA B.; PESSOA, RAFAEL S.; FUJIMORI, MAHMI; DABOIN, BLANCA E. G.; FRANCA, EDUARDO L.; HONORIO-FRANCA, ADENILDA C.. Obesity as an Inflammatory Agent Can Cause Cellular Changes in Human Milk due to the Actions of the Adipokines Leptin and Adiponectin. CELLS, v. 8, n. 6, JUN 2019. (15/01051-3, 15/19922-0)

BRAGA ROCHA, ELIDA MARA; DE ABREU, LUIZ CARLOS; LOPES, AMANDA FORSTER; LEONE, CLAUDIO; VIEIRA, PATRICIA DORE; PINHEIRO BEZERRA, ITALLA MARIA; SZARFARC, SOPHIA CORNBLUTH. Relation of Food Insecurity and Hemoglobin Level in Preschool Aged Children. ANEMIA, v. 2018, p. 7-pg., 2018-01-01. (15/19922-0)