Anti-obesity effects of nutrients by hypothalamic FFA1 and FFA4 activation

• Grant number: 15/50278-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: April 01, 2016
• End date: June 30, 2019
• Field of knowledge: Health Sciences - Nutrition
• Agreement: Innovation Fund Denmark
• Principal Investigator: Licio Augusto Velloso
• Grantee: Licio Augusto Velloso
• Principal researcher abroad: Trond Ulven
• Institution abroad: University of Southern Denmark (SDU), Denmark
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 18/25088-1 - Analysis of paracellular permeability and gut microbiota composition in murine model under high fat diet, BP.IC; 18/20332-1 - The effects of the consumption of monounsaturated fatty acids for four weeks on non-alcoholic fatty liver disease in human adults and Swiss mice, BP.IC; 18/01360-4 - Characterization of the role of the GPR40 receptor in the modulation of precursors of POMC neurons in the adult hypothalamus and its influence on the control of energy homeostasis, BP.PD

Abstract

The main objectives of the project are to elucidate the effect of activation of the long-chain fatty acid receptors FFA4 and FFA1 in the hypothalamus on appetite and obesity; determine the ability of fatty acids in various forms, including as free fatty acids, triacylglycerides, and phospholipids, to reach the central CNS after oral intake and investigate the ability of dietary fatty acids on various forms to counteract obesity through activation of hypothalamic FFA4 and FFA1. The aim is that this will contribute to dietary schemes or active food ingredients ("nutraceuticals") that can represent efficient low-cost strategies to counteract obesity. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

HADDAD-TOVOLLI, ROBERTA; DRAGANO, NATHALIA R. V.; RAMALHO, ALBINA F. S.; VELLOSO, LICIO A.. Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control. FRONTIERS IN NEUROSCIENCE, v. 11, APR 21 2017. (15/50278-0, 15/02913-9, 14/26942-5, 16/01868-2, 13/07607-8)