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Anti-obesity effects of nutrients by hypothalamic FFA1 and FFA4 activation


The main objectives of the project are to elucidate the effect of activation of the long-chain fatty acid receptors FFA4 and FFA1 in the hypothalamus on appetite and obesity; determine the ability of fatty acids in various forms, including as free fatty acids, triacylglycerides, and phospholipids, to reach the central CNS after oral intake and investigate the ability of dietary fatty acids on various forms to counteract obesity through activation of hypothalamic FFA4 and FFA1. The aim is that this will contribute to dietary schemes or active food ingredients ("nutraceuticals") that can represent efficient low-cost strategies to counteract obesity. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HADDAD-TOVOLLI, ROBERTA; DRAGANO, NATHALIA R. V.; RAMALHO, ALBINA F. S.; VELLOSO, LICIO A.. Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control. FRONTIERS IN NEUROSCIENCE, v. 11, . (13/07607-8, 15/02913-9, 15/50278-0, 16/01868-2, 14/26942-5)

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