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Effect of aerobic physical training in molecular, metabolic, hormonal parameters and body composition in women with polycystic ovary syndrome: a clinical controlled trial

Grant number: 15/14031-0
Support type:Regular Research Grants
Duration: May 01, 2016 - October 31, 2018
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Rosana Maria dos Reis
Grantee:Rosana Maria dos Reis
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Assoc. researchers:Hugo Celso Dutra de Souza


Treatment of Polycystic Ovary Syndrome (PCOS) has been directed to the promotion and prevention of cardiovascular and metabolic health. Changes in lifestyle, especially those related to physical exercise, has been identified in order to promote better health. However, there is a lack of studies involving aerobic training and, moreover, does not know its effects on telomere length. The objective of this study is to evaluate the effects of aerobic exercise training in women with PCOS on telomere length, body composition and endocrine-metabolic parameters. It is controlled with random assignment, with randomization stratified by BMI of participants in 3 parallel groups trial: continuous aerobic training, intermittent aerobic training and group without training (control group), in the proportion of 1:1:2. The evaluations will take place before and after 16 weeks of exercise training intervention or observation in the control group. SHBG, lipid profile, glucose and fasting insulin, C-reactive protein and homocysteine - Plasma levels of testosterone, androstenedione, estradiol, binding globulin sex hormones are made. Telomere length is evaluated by real-time PCR and body composition measures by waist circumference and hip, the skinfold method, bioimpedance, and dual energy X-ray absorptiometry. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RIBEIRO, VICTOR BARBOSA; LOPES, IRIS PALMA; DOS REIS, ROSANA MARIA; SILVA, RAFAEL COSTA; MENDES, MARIA CELIA; MELO, ANDERSON SANCHES; DUTRA DE SOUZA, HUGO CELSO; FERRIANI, RUI ALBERTO; KOGURE, GISLAINE SATYKO; DA SILVA LARA, LUCIA ALVES. Continuous versus intermittent aerobic exercise in the improvement of quality of life for women with polycystic ovary syndrome: A randomized controlled trial. JOURNAL OF HEALTH PSYCHOLOGY, SEP 2019. Web of Science Citations: 1.
KOGURE, GISLAINE SATYKO; RIBEIRO, VICTOR BARBOSA; LOPES, IRIS PALMA; MIRANDA FURTADO, CRISTIANA LIBARDI; KODATO, SERGIO; SILVA DE SA, MARCOS FELIPE; FERRIANI, RUI ALBERTO; DA SILVA LARA, LUCIA ALVES; DOS REIS, ROSANA MARIA. Body image and its relationships with sexual functioning, anxiety, and depression in women with polycystic ovary syndrome. Journal of Affective Disorders, v. 253, p. 385-393, JUN 15 2019. Web of Science Citations: 1.
LOPES, IRIS PALMA; RIBEIRO, VICTOR BARBOSA; REIS, ROSANA MARIA; SILVA, RAFAEL COSTA; DUTRA DE SOUZA, HUGO CELSO; KOGURE, GISLAINE SATYKO; FERRIANI, RUI ALBERTO; DA SILVA LARA, LUCIA ALVES. Comparison of the Effect of Intermittent and Continuous Aerobic Physical Training on Sexual Function of Women With Polycystic Ovary Syndrome: Randomized Controlled Trial. Journal of Sexual Medicine, v. 15, n. 11, p. 1609-1619, NOV 2018. Web of Science Citations: 4.

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