Advanced search
Start date
Betweenand

Photosensitization and photodamage of cells and biomimetic models by pterin derivatives

Grant number: 16/04296-0
Support type:Research Grants - Visiting Researcher Grant - International
Duration: June 15, 2016 - August 14, 2016
Field of knowledge:Biological Sciences - Biophysics
Principal Investigator:Mauricio da Silva Baptista
Grantee:Mauricio da Silva Baptista
Visiting researcher: Mariana Vignoni
Visiting researcher institution: Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Argentina
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:12/50680-5 - Photosensitization in life sciences, AP.TEM

Abstract

Pterins, heterocyclic compounds present in living systems, are well-known type I (electron-transfer) and type II (singlet oxygen) photosensitizers under UVA irradiation. They can photoinduce oxidation of nucleotides, DNA, proteins and membrane lipids. This project aims to study the cellular uptake of dihydrobiopterin, one of the most relevant pterins from a biological point of view, the photoconversion to biopterin and the generation of singlet molecular oxygen and other reactive oxygen species inside the cell, using advanced microscopy techniques, such as Fluorescence Lifetime Imaging Microscopy. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIGNONI, MARIANA; NOEL URRUTIA, MARIA; JUNQUEIRA, HELENA C.; GREER, ALEXANDER; REIS, ANA; BAPTISTA, MAURICIO S.; ITRI, ROSANGELA; THOMAS, ANDRES H. Photo-Oxidation of Unilamellar Vesicles by a Lipophilic Pterin: Deciphering Biomembrane Photodamage. Langmuir, v. 34, n. 50, p. 15578-15586, DEC 18 2018. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Distribution map of accesses to this page
Click here to view the access summary to this page.