Multicomponent processes to synthesize new compounds of pharmacological interest - Part 2

• Grant number: 16/04896-7
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2016
• End date: June 30, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Paulo Marcos Donate
• Grantee: Paulo Marcos Donate
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Shirley Muniz Machado Rodrigues

Abstract

This research project aims to develop new synthetic methods to obtain derivatives of various types of gamma-butyrolactone by multicomponent processes. These compounds have great structural diversity and can provide a library of compounds to aid chemo-medicinal studies. First, we intend to test new multicomponent synthetic approaches whose studies have been initiated in our research group. Then, we intend to improve these procedures by replacing the catalytic systems and the solvents and/or by using heating by microwave irradiation and ultrasound. In this way, we expect to synthesize several compounds, such as biologically active derivatives of natural products, effectively and obtain new compounds of pharmacological interest. Purification of the synthesized products and their adequate structural elucidation by various spectroscopic methods will be necessary. Subsequently, we will conduct various kinds of biological assays using the obtained compounds. This last part of the project will have the collaboration of researchers from the Faculty of Pharmaceutical Sciences of Ribeirão Preto/USP, UNESP, University of Franca, and Federal University of ABC, with which we maintain collaborative projects. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PREVIDI, DANIEL; NARDINI, VIVIANI; ROSA, MAYLA EDUARDA; PALARETTI, VINICIUS; JOSE DA SILVA, GIL VALDO; DONATE, PAULO MARCOS. Stereochemical assignment of four diastereoisomers of a maculalactone derivative by computational NMR calculations. Journal of Molecular Structure, v. 1178, p. 467-478, FEB 15 2019. (13/18254-9, 15/05454-5, 16/04896-7)

DONATE, PAULO MARCOS; BARBOSA, HUGO ELIAS. Microwave Radiation Applied to the Synthesis of gamma-butyrolactone Derivatives. ORBITAL-THE ELECTRONIC JOURNAL OF CHEMISTRY, v. 13, n. 4, p. 376-384, JUL-SEP 2021. (16/04896-7, 18/24680-4)

PREVIDI, DANIEL; ROSA, MAYLA EDUARDA; DONATE, PAULO MARCOS. Fast and Efficient Synthesis of Maculalactone Derivatives via the Micro-wave Technique. CURRENT MICROWAVE CHEMISTRY, v. 4, n. 3, p. 229-237, 2017. (13/18254-9, 15/05454-5, 16/04896-7)

RODRIGUES, SHIRLEY M. M.; PREVIDI, DANIEL; BAVIERA, GIOVANNI S.; MATIAS, ALEXANDRE A.; DONATE, PAULO M.. Niobium Pentachloride Mediated (Hetero)aromatic Aldehyde Friedel-Crafts Hydroxyalkylation with Arenes: An Efficient Strategy to Synthesize Triarylmethanes. SYNTHESIS-STUTTGART, v. 51, n. 23, p. 4498-4506, DEC 3 2019. (18/24680-4, 16/04896-7)

PREVIDI, DANIEL; RODRIGUES, STEPHANIE; COELHO, MIKE G.; CANDIDO, ANA CAROLINA B. B.; MAGALHAES, LIZANDRA G.; DONATE, PAULO M.. Synthesis and Antileishmanial Activity of Some Functionalized Peptoids. Journal of the Brazilian Chemical Society, v. 30, n. 6, p. 1334-1340, JUN 2019. (15/05627-7, 16/04896-7)

SILVA, WESLEY R.; MATSUBARA, ELAINE Y.; ROSOLEN, JOSE M.; DONATE, PAULO M.; GUNNELLA, ROBERTO. Pd catalysts supported on different hydrophilic or hydrophobic carbonaceous substrate for furfural and 5-(hydroxymethyl)-furfural hydrogenation in water. MOLECULAR CATALYSIS, v. 504, MAR 2021. (18/24680-4, 17/04759-2, 16/04896-7)