Protein quality control in dysfunctional/atrophic skeletal muscle: roke of B2 adrenoceptor

• Grant number: 15/50429-9
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2016
• End date: May 31, 2018
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Agreement: University of California, Davis (UC Davis)
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Julio Cesar Batista Ferreira
• Grantee: Julio Cesar Batista Ferreira
• Principal researcher abroad: Sue Carol Bodine
• Institution abroad: University of California, Davis (UC Davis), United States
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 15/20783-5 - Protein quality control in dysfunctional/atrophic skeletal muscle: role of b2-adrenoceptor, AP.R

Abstract

Our current results demonstrate that intracellular protein quality control [machinery that detects, repairs and disposes cytotoxic proteins] is impaired during muscle dysfunction and wasting. We also show that pharmacological activation of β2-adrenoceptor induces an overall improvement of protein quality control-related mechanisms in skeletal muscle. Our next step is to establish a causal relationship between 112-adrenoceptor activation and improved protein quality control in skeletal muscle. We expect that disruption of intracellular protein quality control components such as proteasome and lysosome will abolish the benefits off12- adrenoceptor activation in a rodent model of sciatic nerve constriction. Although we use an animal model of muscle dysfunction induced by neural trauma, our rationale could be useful for other skeletal muscle disorders related to disrupted intracellular protein quality control such as muscular dystrophies and aging. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAMPOS, JULIANE C.; BAEHR, LESLIE M.; FERREIRA, NIKOLAS D.; BOZI, LUIZ H. M.; ANDRES, ALLEN M.; RIBEIRO, MARCIO A. C.; GOTTLIEB, ROBERTA A.; BODINE, SUE C.; FERREIRA, JULIO C. B.. beta(2)-adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy. FASEB JOURNAL, v. 34, n. 4, FEB 2020. (18/18627-3, 16/01633-5, 17/16540-5, 12/14416-1, 15/50429-9, 17/16694-2)