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Protein quality control in dysfunctional/atrophic skeletal muscle: role of b2-adrenoceptor

Grant number: 15/20783-5
Support type:Regular Research Grants
Duration: April 01, 2016 - March 31, 2018
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Julio Cesar Batista Ferreira
Grantee:Julio Cesar Batista Ferreira
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo, SP, Brazil
Assoc. researchers:Marcelo Alves da Silva Mori
Associated grant(s):15/50429-9 - Protein Quality Control in dysfunctional/atrophic skeletal muscle: roke of B2 adrenoceptor, AP.R


The cellular protein quality control (PQC) machinery detects repairs and disposes cytotoxic proteins through different proteolytic systems (i.e. ubiquitin-proteasome system and autophagy). We recently demonstrated that improving PQC protects against cardiac diseases. Here, we are going to characterize the PQC profile as well as the benefits of sustained ²2-adrenoceptor activation, a positive PQC modulator, during skeletal muscle degeneration in a rat model of sciatic nerve constriction (SNC). (AU)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, JULIO C. B.; CAMPOS, JULIANE C.; QVIT, NIR; QI, XIN; BOZI, LUIZ H. M.; BECHARA, LUIZ R. G.; LIMA, VANESSA M.; QUELICONI, BRUNO B.; DISATNIK, MARIE-HELENE; DOURADO, PAULO M. M.; KOWALTOWSKI, ALICIA J.; MOCHLY-ROSEN, DARIA. A selective inhibitor of mitofusin 1-beta IIPKC association improves heart failure outcome in rats. NATURE COMMUNICATIONS, v. 10, JAN 18 2019. Web of Science Citations: 0.
KIYUNA, LIGIA AKEMI; PRESTES E ALBUQUERQUE, RUDA; CHEN, CHE-HONG; MOCHLY-ROSEN, DARIA; BATISTA FERREIRA, JULIO CESAR. Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities. Free Radical Biology and Medicine, v. 129, p. 155-168, DEC 2018. Web of Science Citations: 1.
CAMPOS, JULIANE C.; BAEHR, LESLIE M.; GOMES, KATIA M. S.; BECHARA, LUIZ R. G.; VOLTARELLI, VANESSA A.; BOZI, LUIZ H. M.; RIBEIRO, MARCIO A. C.; FERREIRA, NIKOLAS D.; MOREIRA, JOSE B. N.; BRUM, PATRICIA C.; BODINE, SUE C.; FERREIRA, JULIO C. B. Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy. SCIENTIFIC REPORTS, v. 8, AUG 7 2018. Web of Science Citations: 1.
UETA, CINTIA BAGNE; CAMPOS, JULIANE CRUZ; PRESTES E ALBUQUERQUE, RUDA; LIMA, VANESSA MORAIS; DISATNIK, MARIE-HELENE; SANCHEZ, ANGELICA BIANCHINI; CHEN, CHE-HONG; GENNARI DE MEDEIROS, MARISA HELENA; YANG, WENJIN; MOCHLY-ROSEN, DARIA; BATISTA FERREIRA, JULIO CESAR. Cardioprotection induced by a brief exposure to acetaldehyde: role of aldehyde dehydrogenase 2. Cardiovascular Research, v. 114, n. 7, p. 1006-1015, JUN 1 2018. Web of Science Citations: 3.
UETA, CINTIA B.; GOMES, KATIA S.; RIBEIRO, MARCIO A.; MOCHLY-ROSEN, DANIA; FERREIRA, JULIO C. B. Disruption of mitochondrial quality control in peripheral artery disease: New therapeutic opportunities. PHARMACOLOGICAL RESEARCH, v. 115, p. 96-106, JAN 2017. Web of Science Citations: 6.
CAMPOS, JULIANE C.; QUELICONI, BRUNO B.; BOZI, LUIZ H. M.; BECHARA, LUIZ R. G.; DOURADO, PAULO M. M.; ANDRES, ALLEN M.; JANNIG, PAULO R.; GOMES, KATIA M. S.; ZAMBELLI, VANESSA O.; ROCHA-RESENDE, CIBELE; GUATIMOSIM, SILVIA; BRUM, PATRICIA C.; MOCHLY-ROSEN, DARIA; GOTTLIEB, ROBERTA A.; KOWALTOWSKI, ALICIA J.; FERREIRA, JULIO C. B. Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure. AUTOPHAGY, v. 13, n. 8, p. 1304-1317, 2017. Web of Science Citations: 12.
CAMPOS, JULIANE C.; BOZI, LUIZ H. M.; BECHARA, LUIZ R. G.; LIMA, VANESSA M.; FERREIRA, JULIO C. B. Mitochondrial Quality Control in Cardiac Diseases. FRONTIERS IN PHYSIOLOGY, v. 7, OCT 21 2016. Web of Science Citations: 10.

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