Evaluation of periodontal treatment in bronchiectasic patients

• Grant number: 15/20535-1
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2016
• End date: December 31, 2018
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Anna Carolina Ratto Tempestini Horliana
• Grantee: Anna Carolina Ratto Tempestini Horliana
• Host Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil
• Associated researchers: Fernanda de Cordoba Lanza ; Kristianne Porta Santos Fernandes ; Marcia Pinto Alves Mayer ; Priscila Larcher Longo ; Rafael Stelmach ; Raquel Agnelli Mesquita Ferrari ; Rodrigo Abensur Athanazio ; Samia Zahi Rached ; Sandra Kalil Bussadori ; Simone Dal Corso

Abstract

The association between periodontal disease (PD) and chronic obstructive pulmonary disease (COPD) has been greatly studied and aspiration of periodontopathogens is one of the most accepted causal mechanisms for pulmonary exacerbation. The periodontal treatment was associated with decrease of these exacerbations. The bronchiectasis has many clinical similarities with COPD, but so far the relationship with PD has not been studied yet. Therefore, the hypothesis to be tested is whether bronchiectasis is associated with PD, and if periodontal therapy may reflect positively in the improvement of clinical parameters of bronchiectasis. Objective-Evaluate the prevalence of PD in bronchiectasic paired with healthy patients and evaluate if periodontal therapy may result in alteration in the quantity of bronchiectasis exacerbations. Methods: This study will be divided in: phase 1 will be verified the prevalence of PD in bronchiectasic patients (n = 143) matched with healthy controls. They undergo periodontal clinical examination and will respond to three questionnaires for assessing quality of life. In stage 2, bronchiectasic patients with PD are randomly allocated into two groups: G1 control (n=20) will receive supragingival scaling (RS) and orientation for oral hygiene (OH) every 3 months; while the experimental group G2 (n=20) will receive full mouth disinfection and OH every 3 months. At baseline and after 24 months, quantity of exacerbation, clinical pulmonary data by means of anamnesis, periodontal condition by means of clinical examination and three questionnaires of quality of life will be applied. Samples of saliva, nasal lavage and sputum will be collected, and determined the level and proportion of P. aeruginosa, S. aureus and P. gingivalis will be determined by qPCR. Furthermore, the assessment of oral halitosis through Chroma®. This data will allow to evaluate whether periodontal treatment may interfere in the clinical parameters of bronchiectasis and periodontal disease. It is expected that periodontal treatment contributes to the improvement of systemic clinical condition of the patient and therefore with their quality of life. Through further in vivo studies, we will investigate the underlying mechanism of action that associates these two diseases, using the microbiological data obtained in this preliminary study. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CANDEO, LARISSA CARBONERA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; BRITO, AURILEIA APARECIDA; MARCOS, RODRIGO LABAT; FRANCA, CRISTIANE MIRANDA; SANTOS FERNANDES, KRISTIANNE PORTA; MESQUITA-FERRARI, RAQUEL AGNELLI; BUSSADORI, SANDRA KALIL; VIEIRA, RODOLFO PAULA; LINO-DOS-SANTOS-FRANCO, ADRIANA; et al. Effects of periodontitis on the development of asthma: The role of photodynamic therapy. PLoS One, v. 12, n. 11, NOV 16 2017. (15/20535-1, 12/16498-5, 15/23152-6, 15/00830-9)

MURAKAMI-MALAQUIAS-DA-SILVA, FELIPE; ROSA, ELLEN PERIM; OLIVEIRA, JESSICA GONZAGA; AVELAR, ISABELLA SENA; PALMA-CRUZ, MARLON; FERNANDES SILVA, JOAO GABRIEL; RIGONATO-OLIVEIRA, NICOLE CRISTINE; BUSSADORI, SANDRA KALIL; NEGREIROS, RENATA MATALON; LIGEIRO-DE-OLIVEIRA, ANA PAULA; et al. The role of periodontal treatment associated with photodynamic therapy on the modulation of systemic inflammation in the experimental model of asthma and periodontitis. Photodiagnosis and Photodynamic Therapy, v. 29, MAR 2020. (15/20535-1)

SAMPAIO-FILHO, HELIO; BUSSADORI, SANDRA KALIL; LEAL GONCALVES, MARCELA LETICIA; TEIXEIRA DA SILVA, DANIELA DE FATIMA; BORSATTO, MARIA CRISTINA; TORTAMANO, ISABEL PEIXOTO; LONGO, PRISCILA LARCHER; PAVANI, CHRISTIANE; SANTOS FERNANDES, KRISTIANNE PORTA; MESQUITA-FERRARI, RAQUEL AGNELLI; et al. Low-level laser treatment applied at auriculotherapy points to reduce postoperative pain in third molar surgery: A randomized, controlled, single-blinded study. PLoS One, v. 13, n. 6, JUN 19 2018. (15/20535-1)

MURAKAMI-MALAQUIAS-SILVA, FELIPE; ROSA, ELLEN PERIM; MALAVAZZI, TAINA CAROLINE SANTOS; SILVA, TAMIRIS; SARMENTO, DMITRY JOSE DE SANTANA; GARCEZ, AGUINALDO SILVA; FERNANDES, MARCELLA UEDA R.; TORTAMANO, ANDRE; RAMALHO, KAREN MULLER; MOTTA, LARA JANSISKI; et al. Photobiomodulation increases uprighting tooth movement and modulates IL-1β expression during orthodontically bone remodeling. Journal of Biophotonics, v. 16, n. 9, p. 12-pg., 2023-06-21. (15/20535-1)

SAMPAIO-FILHO, HELIO; SOTTO-RAMOS, JULIANE; PINTO, ERIKA HORACIO; CABRAL, MARCIA REGINA; LONGO, PRISCILA LARCHER; TORTAMANO, ISABEL PEIXOTO; MARCOS, RODRIGO LABAT; TEIXEIRA SILVA, DANIELA FATIMA; PAVANI, CHRISTINE; RATTO TEMPESTINI HORLIANA, ANNA CAROLINA. Evaluation of low-level laser at auriculotherapy points to reduce postoperative pain in inferior third molar surgery: study protocol for a randomized controlled trial. Trials, v. 17, SEP 2 2016. (15/20535-1)