Synthesis and structural characterization of cocrystals for application as sunscreen and antioxidants of topical use

• Grant number: 15/26233-7
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2016
• End date: July 31, 2018
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Fabio Furlan Ferreira
• Grantee: Fabio Furlan Ferreira
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Santo André , SP, Brazil
• City of the host institution: Santo André
• Associated researchers: André Rolim Baby ; Fanny Nascimento Costa ; Gabriel Lima Barros de Araujo ; Juliana Alves Pereira Sato

Abstract

A co-crystal may be understood as the junction of two neutral components in a crystalline form in order to improve the solid state properties of pharmaceutical compounds, especially those related to water solubility. Different methodologies to obtain cocrystals can be found in the literature, and the crystallization from the melt, from solution and solvent-drop grinding are the most used ones.Rutin, an active pharmaceutical ingredient with potential applications in sunscreen and antioxidants creams, and which presents low water solubility, will be used as a standard to obtain different cocrystals using various solvents, co-former agents and crystallization techniques. In addition, ferulic acid, a potent phenolic antioxidant found in high concentrations in plants, and which has a high sunscreen potential will be used in conjunction with rutin in an attempt to obtain new cocrystals.The structural characterization of the formed compounds will be performed mainly with the use of X-ray powder diffraction. The data obtained using this experimental technique will then be used in the process of structural determination of the obtained samples, with the structures being refined using the Rietveld method.In this research project we will carry out the synthesis and characterization of cocrystals of rutin and ferulic acid, aiming the formation of new crystalline forms with potential applications in sunscreens and antioxidants creams. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FREITAS, JENNIFER T. J.; DE MELO, CRISTIANE C.; VIANA, OLIMPIA M. M. S.; FERREIRA, FABIO F.; DORIGUETTO, ANTONIO C.. Crystal Structure of Levofloxacin Anhydrates: A High-Temperature Powder X-ray Diffraction Study Versus Crystal Structure Prediction. Crystal Growth & Design, v. 18, n. 6, p. 3558-3568, JUN 2018. (15/26233-7)

DE OLIVEIRA, RAMON GUERRA; GUERRA, FABIANA SELOS; MERMELSTEIN, CLAUDIA DOS SANTOS; FERNANDES, PATRICIA DIAS; DE SENA BASTOS, ISADORA TAIRINNE; COSTA, FANNY NASCIMENTO; RODRIGUES BARROSO, REGINA CELY; FERREIRA, FABIO FURLAN; MANSSOUR FRAGA, CARLOS ALBERTO. Synthesis and pharmacological evaluation of novel isoquinoline N-sulphonylhydrazones designed as ROCK inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 33, n. 1, p. 1181-1193, JUL 25 2018. (15/26233-7)

TESCH, ROBERTA; BECKER, CHRISTIAN; MUELLER, MATTHIAS PHILIPP; BECK, MICHAEL EDMUND; QUAMBUSCH, LENA; GETLIK, MATTHAUS; LATEGAHN, JONAS; UHLENBROCK, NIKLAS; COSTA, FANNY NASCIMENTO; POLETO, MARCELO D.; et al. An Unusual Intramolecular Halogen Bond Guides Conformational Selection. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 57, n. 31, p. 9970-9975, JUL 26 2018. (15/26233-7)

BRITOS, TATIANE N.; CASTRO, CARLOS E.; BERTASSOLI, BRUNO M.; PETRI, GIULIANA; FONSECA, FERNANDO L. A.; FERREIRA, FABIO F.; HADDAD, PAULA S.. In vivo evaluation of thiol-functionalized superparamagnetic iron oxide nanoparticles. Materials Science & Engineering C-Materials for Biological Applications, v. 99, p. 171-179, JUN 2019. (16/22221-7, 17/15061-6, 11/19924-2, 15/26233-7)

DE ARAUJO, GABRIEL L. B.; FERREIRA, FABIO FURLAN; BERNARDES, CARLOS E. S.; SATO, JULIANA A. P.; GIL, OTAVIO M.; DE FARIA, DALVA L. A.; LOEBENBERG, RAIMAR; BYRN, STEPHEN R.; GHISLENI, DANIELA D. M.; BOU-CHACRA, NADIA A.; et al. A New Thermodynamically Favored Flubendazole/Maleic Acid Binary Crystal Form: Structure, Energetics, and in Silico PBPK Model-Based Investigation. Crystal Growth & Design, v. 18, n. 4, p. 2377-2386, APR 2018. (15/05685-7, 15/26233-7)

DO PRADO, VANIA M.; DE QUEIROZ, THIAGO B.; SA, PAULA M.; SEICEIRA, RAFAEL C.; BOECHAT, NUBIA; FERREIRA, FABIO F.. Mechanochemistry for the production of a hybrid salt used in the treatment of malaria. GREEN CHEMISTRY, v. 22, n. 1, p. 54-61, JAN 7 2020. (15/26233-7)

DE OLIVEIRA, RAMON GUERRA; GUERRA, FABIANA SELOS; MERMELSTEIN, CLAUDIA DOS SANTOS; FERNANDES, PATRICIA DIAS; DE SENA BASTOS, ISADORA TAIRINNE; COSTA, FANNY NASCIMENTO; RODRIGUES BARROSO, REGINA CELY; FERREIRA, FABIO FURLAN; MANSSOUR FRAGA, CARLOS ALBERTO. Synthesis and pharmacological evaluation of novel isoquinoline N-sulphonylhydrazones designed as ROCK inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 33, n. 1, p. 13-pg., 2018-07-25. (15/26233-7)