Neurocognitive markers for the early and differential diagnosis for Alzheimer´s disease and frontotemporal dementia

• Grant number: 16/07967-2
• Support Opportunities: Regular Research Grants
• Duration: August 01, 2016 - January 31, 2019
• Field of knowledge: Humanities - Psychology - Human Development Psychology
• Principal Investigator: Monica Sanches Yassuda
• Grantee: Monica Sanches Yassuda
• Host Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Artur Martins Novaes Coutinho ; Mario Amore Cecchini ; Sonia Maria Dozzi Brucki

Abstract

Epidemiological studies indicate that the prevalence of dementia will grow more intensely in low and middle income countries. There is great interest in identifying neurocognitive markers that can assist in the early diagnosis of the dementias. The visual short-term memory binding test (VSMB) has been indicated as a promising cognitive marker for identifying pre-clinical Alzheimer's disease (AD). Objectives: Study 1. Assess whether the VSMB test can differentiate cognitively normal elderly (CN) from patients with mild cognitive impairment (MCI) and AD; Study 2. Investigate innovative cognitive tests based on social cognition to support the early diagnosis of behavioral variant frontotemporal dementia (bvFTD). Methods: Study 1: 30 CN individuals, 30 diagnosed with MCI and 30 with AD will be assessed with a neuropsychological battery that will include the VSMB test, applied in its version for tablets. Study 2: 30 CN individuals will be compared to 30 elderly diagnosed with bvFTD and 30 AD patients. The neuropsychological battery will contain the VSMB, laptop version, and social cognition measures: the Mini Social Cognition and Emotional Assessment (Mini-SEA) and the Ultimatum Game paradigm. In all three studies the diagnosis of CN, MCI, AD and bvFTD will be performed by experienced neurologists supported by a multidisciplinary team according to international criteria. These studies are expected to contribute to the early and differential diagnosis of AD and bvFTD by providing innovative cognitive markers so that families can be supported properly during the early diagnosis and treatment of these conditions. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIMA-SILVA, THAIS BENTO; MIOSHI, ENEIDA; BAHIA, VALERIA SANTORO; CECCHINI, MARIO AMORE; CASSIMIRO, LUCIANA; GUIMARAES, HENRIQUE CERQUEIRA; GAMBOGI, LEANDRO BOSON; CARAMELLI, PAULO; BALTHAZAR, MARCIO; DAMASCENO, BENITO; et al. Disease Progression in Frontotemporal Dementia and Alzheimer Disease: The Contribution of Staging Scales. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, AUG 2020. (16/07967-2, 11/04804-1)

LIMA-SILVA, THAIS BENTO; MIOSHI, ENEIDA; BAHIA, VALERIA SANTORO; CECCHINI, MARIO AMORE; CASSIMIRO, LUCIANA; GUIMARAES, HENRIQUE CERQUEIRA; GAMBOGI, LEANDRO BOSON; CARAMELLI, PAULO; BALTHAZAR, MARCIO; DAMASCENO, BENITO; et al. Disease Progression in Frontotemporal Dementia and Alzheimer Disease: The Contribution of Staging Scales. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, v. 34, n. 5, p. 397-404, SEP 2021. (11/04804-1, 16/07967-2)

CECCHINI, MARIO AMORE; YASSUDA, MONICA SANCHES; SQUARZONI, PAULA; COUTINHO, ARTUR MARTINS; FARIA, DANIELE DE PAULA; DE SOUZA DURAN, FABIO LUIZ; DA COSTA, NAOMI ANTUNES; DE GOBBI PORTO, FABIO HENRIQUE; NITRINI, RICARDO; FORLENZA, ORESTES VICENTE; et al. Deficits in short-term memory binding are detectable in individuals with brain amyloid deposition in the absence of overt neurodegeneration in the Alzheimer's disease continuum. BRAIN AND COGNITION, v. 152, AUG 2021. (14/50873-3, 16/50197-3, 12/50329-6, 16/07967-2)

DA SILVA, THAIS BENTO LIMA; ORDONEZ, TIAGO NASCIMENTO; BREGOLA, ALLAN GUSTAVO; BAHIA, VALERIA SANTORO; CECCHINI, MARIO AMORE; GUIMARAES, HENRIQUE CERQUEIRA; GAMBOGI, LEANDRO BOSON; CARAMELLI, PAULO; BALTHAZAR, MARCIO LUIZ FIGUEREDO; DAMASCENO, BENITO PEREIRA; et al. Neuropsychiatric Symptoms in Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease: A 12-Month Follow-Up Study. FRONTIERS IN NEUROLOGY, v. 12, SEP 30 2021. (16/07967-2, 11/04804-1)

ALLAN GUSTAVO BRIGOLA; TIAGO DA SILVA ALEXANDRE; KEIKA INOUYE; MONICA SANCHES YASSUDA; SOFIA CRISTINA IOST PAVARINI; ENEIDA MIOSHI. Associação entre baixa escolaridade, desempenho cognitivo reduzido, incapacidade funcional e fragilidade em idosos. Dement. Neuropsychol., v. 13, n. 2, p. 216-224, 2019-06-18. (16/07967-2, 13/26798-9, 17/04129-9, 14/23898-5)