Acmella oleracea and Achyrocline satureioides as sources of natural products in topical wound care

• Grant number: 16/13776-5
• Support Opportunities: Regular Research Grants - Publications - Scientific article
• Start date: September 01, 2016
• End date: February 28, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Rodney Alexandre Ferreira Rodrigues
• Grantee: Rodney Alexandre Ferreira Rodrigues
• Host Institution: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA). Universidade Estadual de Campinas (UNICAMP). Paulínia , SP, Brazil

Abstract

The Brazilian forests have one of biggest world's biodiversity. Achyrocline satureioides(macela) and Acmella oleracea (jambu) are native species from Brazil with a hugetherapeutic potential, with proved anti-inflammatory and anesthetic action respectively.The jambu's crude extract after depigmentation with activated charcoal and macela'sessential oil were incorporated in a film made with hydroxyethylcellulose. Those filmswere evaluated by mechanical test using a texturometer, anti-inflammatory andanesthetic activities by in vivo tests: wound healing and antinociceptive. The filmcontaining the highest concentration of depigmented jambu's extract and macela'sessential oil obtained an anesthesia time of 83.6 (±28.5) min longer when comparedwith the positive control EMLA®; the same occurred with the wound healing test, thefilm containing the highest concentration had a higher wound contraction (62.0% ±12.1)compared to the positive control allantoin and the histopathological analysisdemonstrated that it increases collagen synthesis and epidermal thickening. The resultsdemonstrate that the films have a potential use in skin wounds, pressure sore andinfected surgical wounds treatment. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

YAMANE, LAIS THIEMI; DE PAULA, ENEIDA; JORGE, MICHELLE PEDROZA; DE FREITAS-BLANCO, VERONICA SANTANA; MONTANARI JUNIOR, ILIO; FIGUEIRA, GLYN MARA; ANHOLETO, LUIS ADRIANO; DE OLIVEIRA, PATRICIA ROSA; FERREIRA RODRIGUES, RODNEY ALEXANDRE. Acmella oleracea and Achyrocline satureioides as Sources of Natural Products in Topical Wound Care. Evidence-based Complementary and Alternative Medicine, v. 2016, p. 9-pg., 2016-01-01. (16/13776-5)

YAMANE, LAIS THIEMI; DE PAULA, ENEIDA; JORGE, MICHELLE PEDROZA; DE FREITAS-BLANCO, VERONICA SANTANA; MONTANARI JUNIOR, ILIO; FIGUEIRA, GLYN MARA; ANHOLETO, LUIS ADRIANO; DE OLIVEIRA, PATRICIA ROSA; FERREIRA RODRIGUES, RODNEY ALEXANDRE. Acmella oleracea and Achyrocline satureioides as Sources of Natural Products in Topical Wound Care. Evidence-based Complementary and Alternative Medicine, 2016. (16/13776-5)