Study of the antibacterial activity of Achyrocline satureioides extracts

• Grant number: 23/06410-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2023
• End date: October 31, 2024
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Rosemeire Cristina Linhari Rodrigues Pietro
• Grantee: Annelize Rodrigues Gomes
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Countless natural sources have been used as raw materials in the process to obtain new therapeutic products, where a fantastic variety of biosynthesized secondary metabolites has promoted large investments in research. Achyrocline satureioides, popularly known as macela, is an aromatic herb widely used in folk medicine, carrying multiple biological activities, such as analgesic, antimicrobial, antiinflammatory and antioxidant. This plant native to Brazil, Uruguay, Argentina and Paraguay, has chlorogenic acid and quercetin as its main components. The objective of the present project is to carry out the study of the antimicrobial activities, of the extracts and pure substances, originating from the species under study, free and incorporated in microparticles. In this study, bacterial strains will be used, kept in the strain of the Laboratory of Pharmaceutical Biotechnology - BIOTECFAR, of the School of Pharmaceutical Sciences of Araraquara/UNESP. The methodology for the evaluation of antimicrobial activity in vitro will be performed by the method of microdilution in broth for the determination of the Minimum Inhibitory Concentration (MIC).