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Leishmaniasis in Latin America: an advanced perspective on immunopathogenetic factors of cutaneous and visceral infection, immunomodulators of the sandflies vector saliva and immunogenic exo-antigens of Leishmania (L.) infantum chagasi as vaccine candidates

Grant number: 14/50315-0
Support type:Research Projects - Thematic Grants
Duration: October 01, 2016 - September 30, 2021
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal Investigator:Carlos Eduardo Pereira Corbett
Grantee:Carlos Eduardo Pereira Corbett
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Fernando Tobias Silveira ; Marcia Dalastra Laurenti
Associated grant(s):18/18909-9 - 1st international Caparica Congress on leishmaniasis 2018, AR.EXT
Associated scholarship(s):20/02626-8 - Nitric oxide and reactive species of oxygen evaluation in human infection caused by Leishmania (L.) infantum chagasi, BP.TT
19/17957-2 - In situ expression of Th17 profile immune mediators in lesions of patients with American Cutaneous Leishmaniasis caused by Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis, BP.IC
19/13880-5 - Leishmaniasis in Latin America: an advanced perspective on immunopatogenetic factors of cutaneous and visceral infection, BP.PD
+ associated scholarships 19/01726-1 - Detection of Leishmania (L.) infantum chagasi in the oral swab of individuals living in an endemic area for visceral leishmaniasis, BP.TT
18/04698-6 - Non-ulcerated or atipycal Cutaneous Leishmaniasis caused by Leishmania (L.) infantum chagasi in the municipality of Amapala, Valle, Honduras: immunohistopathological characterization of skin lesions with emphasis in the participation of antigen presenting cells, BP.DR
17/24834-9 - Evaluation of the experimental infection in hamster by isolated parasites of atypical cutaneous lesion and human visceral caused by Leishmania (L.) infantum chagasi in the municipality of Amapala, Valle, Honduras, BP.DR
17/03141-5 - Characterization of histopathological changes and cellular immune response in cutaneous lesions of patients with Tegumentary Leishmaniasis in Panamá, BP.DD
16/23789-7 - CD1a + and CD11c + cell expression in patients' skin lesions with non-ulcerated or atypical cutaneous leishmaniasis caused by Leishmania (Leishmania) infantum, BP.IC - associated scholarships


Human leishmaniasis, both the cutaneous or muco-cutaneous forms, as well as the systemic visceral form, remain representing till how, an important public health problem around the world, especially in tropical and subtropical areas of the globe, where geographic, climate and social-economic factors contribute for the maintenance and dispersion of these diseases. In this way, Latin America appears as one of most compromised areas by these injuries, where some countries such as Brazil, in the South America, and Panama and Honduras, in the Central America, present an interesting epidemiological feature due to some peculiarities related not only to the antigenic capacity of Leishmania species, as well as the interaction of these parasites with the human Immune response, resulting in the immunopatogenetic process that can give rise to the tegumentary leishmaniasis or systemic visceral leishmaniasis. The imunopathogenetic basis are one of the targets of greatest interest of this project, which will be Investigated by gene expression and in situ phenotypic markers, trying to better understanding the cell signaling factors and the cytokines profiles of innate and adaptive immune responses of the hosts related to these different forms of the disease. (AU)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVEIRAA, FERNANDO T. What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 113, n. 9, p. 505-516, SEP 2019. Web of Science Citations: 0.
GONZALEZ, K.; CALZADA, J. E.; DIAZ, R.; PAZ, H.; GARCIA, V.; MIRANDA, A.; TOMOKANE, T.; PUGA, S.; SALDANA, A.; LAURENTI, M. Performance of immunohistochemistry as a useful tool for the diagnosis of cutaneous leishmaniasis in Panama, Central America. Parasitology International, v. 71, p. 46-52, AUG 2019. Web of Science Citations: 2.
SANDOVAL PACHECO, CARMEN MARIA; ARAUJO FLORES, GABRIELA VENICIA; FAVERO FERREIRA, AUREA; SOSA OCHOA, WILFREDO; RIBEIRO DA MATTA, VANIA LUCIA; VALERIANO, CONCEPCION ZUNIGA; PEREIRA CORBETT, CARLOS EDUARDO; DALASTRA LAURENTI, MARCIA. Histopathological features of skin lesions in patients affected by non-ulcerated or atypical cutaneous leishmaniasis in Honduras, Central America. International Journal of Experimental Pathology, v. 99, n. 5, p. 249-257, OCT 2018. Web of Science Citations: 0.
CALEGARI-SILVA, TERESA C.; VIVARINI, AISLAN C.; PEREIRA, RENATA DE M. S.; DIAS-TEIXEIRA, KARINA L.; RATH, CAROLINA T.; PACHECO, AMANDA S. S.; SILVA, GABRIELLE B. L.; PINTO, CHARLENE A. S.; DOS SANTOS, JOSE V.; SALIBA, ALESSANDRA M.; CORBETT, CARLOS E. P.; DE CASTRO GOMES, CLAUDIA M.; FASEL, NICOLAS; LOPES, ULISSES G. Leishmania amazonensis downregulates macrophage iNOS expression via Histone Deacetylase 1 (HDAC1): a novel parasite evasion mechanism. European Journal of Immunology, v. 48, n. 7, p. 1188-1198, JUL 2018. Web of Science Citations: 3.
ARAUJO FLORES, GABRIELA VENICIA; SANDOVAL PACHECO, CARMEN MARIA; TOMOKANE, THAISE YUMIE; OCHOA, WILFREDO SOSA; VALERIANO, CONCEPCION ZUNIGA; CASTRO GOMES, CLAUDIA MARIA; PEREIRA CORBETT, CARLOS EDUARDO; LAURENTI, MARCIA DALASTRA. Evaluation of Regulatory Immune Response in Skin Lesions of Patients Affected by Nonulcerated or Atypical Cutaneous Leishmaniasis in Honduras, Central America. Mediators of Inflammation, 2018. Web of Science Citations: 0.

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