Correlation with different clinical stages in patients with Parkinson's disease and neuropathic pain: validation of the Rotterdam Elderly Pain Observation Scale (REPOS)

• Grant number: 15/50089-3
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2016
• End date: September 30, 2018
• Field of knowledge: Health Sciences - Medicine
• Agreement: Erasmus Universiteit Rotterdam
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Lauro Wichert Ana
• Grantee: Lauro Wichert Ana
• Principal researcher abroad: Dick Tibboel
• Institution abroad: Erasmus University Rotterdam (EUR), Netherlands
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 13/25987-2 - Evaluation of the density of presynaptic dopamine Tranporters in humans: development and evaluation of quantitation protocols based on the hybrid SPECT-CT technology using 99mTc-TRODAT-1, AP.R

Abstract

Parkinson’s disease (PD) is a progressive degenerative disease that affects the substantia nigra compact as well as other regions of the brain and other organs. Pain is a distressing non-motor symptom experienced by up 85% of people with PD and is often not expressed being unidentified. The scale of observation of pain in the Elderly (RESET) is a range of observational pain differs from other scales, including adults and seniors with limited communication without needing to communicate verbally, not yet validated for the Portuguese language. We wish to know if the motor changes associated with PD may be hiding the manifestation of pain. Objectives: (a) to monitor, discuss and analyze the application of REPOS in elderly patients at Erasmus MC; (b) Validate the translation of REPOS; (c) application in patients with PD and neuropathic pain. Methodology: will be included 20 healthy volunteers matched with 20 patients with PD and 20 with Neuropathic Pain. Patients should be observed for 2 minutes, during consultation, physical and neurological examination. Prevalence and behaviors of co-occurrences will be analyzed and identified. Will apply to Numeric Rating Scale, and REPOS, will run in the Pain Clinic and Disease Clinic Extra Pyramidal HCFMRP-USP, providing better treatment for patients with Neuropathic Pain and PD. These bilateral missions will encourage meetings, trainings, presentations and publications. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIA, ERICA NEGRINI; PAPASSIDERO, PRISCILA COLAVITE; COELHO, EDUARDO BARBOSA; DACH, FABIOLA; ALEXANDRE-SANTOS, LEONARDO; TREVISAN, ANA CAROLINA; LOPES E SANTOS, LUCAS EMMANUEL; SILVAH, JOSE HENRIQUE; LANCHOTE, VERA LUCIA; DELLA PASQUA, OSCAR; et al. Neurobiological substrates of chronic low back pain (CLBP): a brain [Tc-99m]Tc-ECD SPECT study. EUROPEAN JOURNAL OF HYBRID IMAGING, v. 6, n. 1, p. 10-pg., 2022-11-21. (15/50089-3, 21/12671-3)

PITELLA, FELIPE ARRIVA; TREVISAN, ANA CAROLINA; ALEXANDRE-SANTOS, LEONARDO; KATO, MERY; BRITO, MANUELINA MARIANA CAPELLARI MACRUZ; TUMAS, VITOR; WICHERT-ANA, LAURO. Reference Values for Dopamine Transporter Imaging With Tc-99m-TRODAT-1 in Healthy Subjects and Parkinson's Disease Patients. CLINICAL NUCLEAR MEDICINE, v. 47, n. 9, p. 6-pg., 2022-09-01. (15/50089-3, 21/12671-3, 12/14152-4)

TREVISAN, ANA CAROLINA; ALEXANDRE-SANTOS, LEONARDO; ASSAD, RODRIGO LUPPINO; ITIKAWA, EMERSON NOBUYUKI; PITELLA, FELIPE ARRIVA; KATO, MERY; SILVAH, JOSE HENRIQUE; SANTOS, ANTONIO CARLOS; LOUZADA-JUNIOR, PAULO; WICHERT-ANA, LAURO. Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study. EUROPEAN JOURNAL OF HYBRID IMAGING, v. 5, n. 1, NOV 4 2021. (13/25987-2, 15/50089-3)

PAPASSIDERO, PRISCILA; WICHERT-ANA, LAURO; LIA, ERICA NEGRINI; ALEXANDRE-SANTOS, LEONARDO; TREVISAN, ANA CAROLINA; COELHO, EDUARDO BARBOSA; DELLA PASQUA, OSCAR; LANCHOTE, VERA LUCIA; DACH, FABIOLA. Pharmacodynamic effect of gabapentin on central nervous system in patients with chronic low back pain: a [99mTc]Tc-ECD SPECT study. REGIONAL ANESTHESIA AND PAIN MEDICINE, v. 48, n. 8, p. 6-pg., 2023-03-30. (15/50089-3, 21/12671-3)

SEIXAS-MOIZES, JULIETA; BOERLAGE, ANNEKE; LIA, ERICA NEGRINI; LOPES E SANTOS, LUCAS EMMANUEL; ZUCOLOTO, MIRIANE LUCINDO; DACH, FABIOLA; PAPASSIDERO, PRISCILA COLAVITE; LEAL WICHERT-ANA, LAIS ALMEIDA; DELLA PASQUA, OSCAR; WIESEBRON, MARIANNE LOUISE; et al. Translation, Cross-Cultural Adaptation, and Validation of the Portuguese Version of the Rotterdam Elderly Pain Observation Scale. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA, v. 11, n. 3, p. 10-pg., 2021-01-01. (15/50089-3)