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Effects of handgrip isometric training on blood pressure, endothelial function and cardiac autonomic modulation in patients with peripheral artery disease: a randomized controlled study.

Grant number: 16/16425-9
Support Opportunities:Regular Research Grants
Duration: November 01, 2016 - October 31, 2018
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Raphael Mendes Ritti Dias
Grantee:Raphael Mendes Ritti Dias
Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil
Associated researchers:Gabriel Grizzo Cucato ; Lauro Casqueiro Vianna ; Nelson Wolosker

Abstract

Patients with peripheral arterial disease (PAD) have a high prevalence of hypertension, which contributes to their high cardiovascular risk. Meta-analysis studies have shown that isometric handgrip training (IHT) reduces clinical blood pressure in hypertensive individuals, however, whether similar effects are observed in PAD patients that presents important cardiovascular dysfunction and the possible mechanisms is unknown. Thus, the aim of this study is to analyze the effects of IHT on blood pressure, endothelial function and cardiac autonomic modulation in patients with PAD. In this clinical trial, 90 patients will be randomly allocated into two groups: IHT and control (CG). The IHT will conduct the unilateral handgrip training three days per week (four sets of two minutes, with 30% of maximum voluntary contraction with an interval of four minute between sets). The GC will conduct a sham training, with a physical therapy compression ball, in three sessions per week. All patients, in both groups, will be encouraged to increase the level of activity, as they are usually geared for medical consultation. At baseline, during (fifth week) and after (eighth week) intervention period brachial and central blood pressure, endothelial function, and cardiac autonomic modulation will be obtained. Statistical analysis will be held with two-way ANOVA for repeated measures with the group (IHT and GC) and time (pre, during and post-intervention) as factors, and will be accepted as significant value of P<0.05. (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTINI, LUIZA; CORREIA, MARILIA ALMEIDA; OLIVEIRA, PAULO L.; PUECH-LEAO, PEDRO; WOLOSKER, NELSON; CUCATO, GABRIEL G.; RITTI-DIAS, RAPHAEL M.. Functional and Cardiovascular Parameters in Peripheral Artery Disease Patients with Interarm Blood Pressure Difference. ANNALS OF VASCULAR SURGERY, v. 70, p. 355-361, . (16/16425-9)
RITTI-DIAS, RAPHAEL MENDES; CORREIA, MARILIA DE ALMEIDA; ANDRADE-LIMA, ALUISIO; CUCATO, GABRIEL GRIZZO. Exercise as a therapeutic approach to improve blood pressure in patients with peripheral arterial disease: current literature and future directions. EXPERT REVIEW OF CARDIOVASCULAR THERAPY, v. 17, n. 1, p. 65-73, . (16/16425-9)
OLIVEIRA, PAULO L.; CORREIA, MARILIA A.; WOLOSKER, NELSON; VIANNA, LAURO C.; RITTI-DIAS, RAPHAEL M.; CUCATO, GABRIEL G.. Effect of Sex on Vascular Adaptations to Isometric Handgrip Training in Elderly Patients with Peripheral Artery Disease: A Randomized Controlled Trial. JOURNAL OF VASCULAR RESEARCH, . (16/16425-9)
DA SILVA, GUSTAVO OLIVEIRA; CORREIA, MARILIA DE ALMEIDA; MESQUITA DE OLIVEIRA, PAULO LONGANO; FARAH, BRENO QUINTELLA; VIANNA, LAURO C.; PUECH-LEAO, PEDRO; WOLOSKER, NELSON; CUCATO, GABRIEL GRIZZO; RITTI-DIAS, RAPHAEL MENDES. re Vascular Parameters Associated with Walking Impairment in Patients with Claudication. ANNALS OF VASCULAR SURGERY, v. 77, p. 31-37, . (19/05221-1, 16/16425-9)
RITTI-DIAS, RAPHAEL M.; CORREIA, MARILIA; LONGANO, PAULO; WOLOSKER, NELSON; CUCATO, GABRIEL. Diabetes Impairs Walking Capacity And Autonomic Function In Patients With Peripheral Artery Disease. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 51, n. 6, p. 1-pg., . (16/16425-9)
OLIVEIRA, PAULO L.; CORREIA, MARILIA A.; WOLOSKER, NELSON; VIANNA, LAURO C.; RITTI-DIAS, RAPHAEL M.; CUCATO, GABRIEL G.. Effect of Sex on Vascular Adaptations to Isometric Handgrip Training in Elderly Patients with Peripheral Artery Disease: A Randomized Controlled Trial. JOURNAL OF VASCULAR RESEARCH, v. N/A, p. 4-pg., . (16/16425-9)
CORREIA, MARILIA A.; OLIVEIRA, PAULO L.; FARAH, BRENO Q.; VIANNA, LAURO C.; WOLOSKER, NELSON; PUECH-LEAO, PEDRO; GREEN, DANIEL J.; CUCATO, GABRIEL G.; RITTI-DIAS, RAPHAEL M.. Effects of Isometric Handgrip Training in Patients With Peripheral Artery Disease: A Randomized Controlled Trial. JOURNAL OF THE AMERICAN HEART ASSOCIATION, v. 9, n. 4, . (16/16425-9)
KANEGUSUKU, HELCIO; CUCATO, GABRIEL G.; DOMICIANO, ROMULO M.; LONGANO, PAULO; PUECH-LEAO, PEDRO; WOLOSKER, NELSON; RITTI-DIAS, RAPHAEL M.; CORREIA, MARILIA A.. Impact of obesity on walking capacity and cardiovascular parameters in patients with peripheral artery disease: A cross-sectional study. JOURNAL OF VASCULAR NURSING, v. 38, n. 2, p. 66-71, . (16/16425-9)

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