Proteoglycans profile and micro-RNA expression associated to tumor invasion and prognosis in oral cavity squamous cell carcinoma

• Grant number: 16/01740-6
• Support type: Regular Research Grants
• Duration: February 01, 2017 - July 31, 2019
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal researcher: Leandro Luongo de Matos
• Grantee: Leandro Luongo de Matos
• Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Assoc. researchers: Claudio Roberto Cernea ; Marco Aurelio Vamondes Kulcsar ; Raquel Ajub Moyses

Abstract

Proteglycans are macromecules composed by a specific core protein to witch linear chains of heteropolysaccharides, the glycosaminoglycans, are covalently linked. The proteglycans participate in many functions as angiogenesis, cellular differentiation and proliferation, adhesion, apoptosis, invasion and metastasis. MicroRNAs, small non-coding RNAs with 19 to 25 nucleotides, play critical roles in cellular regulation and also in the microenvironment, which include regulation over proteoglycans. Their expression patterns are associated with cancer development and progression. It is rising the study of microRNAs related to carcinogenesis, tumors progression and maily in the prognosis of patients with squamous cell carcinoma of the oral cavity. For this cancer, tumor thickness, a clinical evidence of the adjacent stroma invasion by the tumor, is a well established and an independent factor of worse prognosis, although the molecular pathways of this process are still poorly understood. In this scenario, the purposes of the present project are to evaluate the role of proteoglycans and microRNAs in the process of tumor invasion, and also to correlate their expression with demographic, histopathological and immunohistochemistry data and the prognosis of patients with oral cavity squamous cell carcinoma. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MATOS, LEANDRO LUONGO; MENDERICO JUNIOR, GILBERTO MENDES; THEODORO, THERESE RACHELL; PASINI, FATIMA SOLANGE; ISHIKAWA, MARINA DE MENEZES; BOMTEMPO RIBEIRO, ANDROMEDA ARYANE; DE MELLO, EVANDRO SOBROZA; DA SILVA PINHAL, MARIA APARECIDA; MOYSES, RAQUEL AJUB; VAMONDES KULCSAR, MARCO AURELIO; DEDIVITIS, ROGERIO APARECIDO; CERNEA, CLAUDIO ROBERTO; KOWALSKI, LUIZ PAULO. Cancer-associated fibroblast regulation by microRNAs promotes invasion of oral squamous cell carcinoma. Oral Oncology, v. 110, NOV 2020. Web of Science Citations: 0.

MATOS, LEANDRO LUONGO; DEDIVITIS, ROGERIO APARECIDO; VAMONDES KULCSAR, MARCO AURELIO; DE MELLO, EVANDRO SOBROZA; ALVES, VENANCIO AVANCINI F.; CERNEA, CLAUDIO ROBERTO. External validation of the AJCC Cancer Staging Manual, 8th edition, in an independent cohort of oral cancer patients. Oral Oncology, v. 71, p. 47-53, AUG 2017. Web of Science Citations: 22.