Brain cortical activity during human locomotion: Influence of aging, Parkinson's disease and acute physical exercise

• Grant number: 16/21499-1
• Support Opportunities: Regular Research Grants
• Duration: February 01, 2017 - July 31, 2019
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Lilian Teresa Bucken Gobbi
• Grantee: Lilian Teresa Bucken Gobbi
• Host Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil
• Associated researchers: Diego Orcioli da Silva ; Ellen Lirani Silva ; Mark Carpenter ; Nubia Ribeiro da Conceição ; Paulo Cezar Rocha dos Santos ; Priscila Nóbrega de Sousa ; Rodrigo Vitório ; Victor Spiandor Beretta

Abstract

Background: Recent studies suggest that the human cerebral cortex is more active during walking than previously reported in the literature. The main evidences of the involvement of the cerebral cortex in human locomotion come from studies using functional magnetic resonance imaging. These studies have an important limitation: the participants were not, in fact, walking during the recording of brain cortical activity. Therefore, a more ecological approach is required in order to confirm the findings from neuroimaging studies. It means to record brain cortical activity during real-world walking tasks. The mobile electroencephalography (EEG) and functional near infrared spectroscopy (NIRS) devices, recently made available on the market, allow the registration of the cerebral cortex activity during real-world walking tasks. Objectives: In this context, the objective of the current research proposal is to investigate the effects of aging (Study #1), Parkinson's disease (PD; Study #1) and acute physical exercise (Study #2) on the activity of the cerebral cortex during real-world walking tasks. Studies: The current proposal involves two innovative research projects with international collaboration. In short, measures of the activity of the cerebral cortex and motor behavior will be recorded while young adults, healthy older adults and patients with PD perform real-world walking tasks. The Study #1 will investigate the effects of aging and PD on the activity of the cerebral cortex during locomotion. The Study #2, a randomized controlled trial, will investigate the acute effect of exercise on the activity of the cerebral cortex during locomotion in patients with PD. (AU)

Scientific publications

(12)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ORCIOLI-SILVA, DIEGO; VITORIO, RODRIGO; NOBREGA-SOUSA, PRISCILA; BERETTA, VICTOR SPIANDOR; DA CONCEICAO, NUBIA RIBEIRO; OLIVEIRA, ANDERSON SOUZA; PEREIRA, MARCELO PINTO; BUCKEN GOBBI, LILIAN TERESA. Cortical Activity Underlying Gait Improvements Achieved With Dopaminergic Medication During Usual Walking and Obstacle Avoidance in Parkinson Disease. NEUROREHABILITATION AND NEURAL REPAIR, MAR 2021. (16/21499-1, 17/19845-1, 14/22308-0)

NOBREGA-SOUSA, PRISCILA; GOBBI, LILIAN TERESA BUCKEN; ORCIOLI-SILVA, DIEGO; DA CONCEICAO, NUBIA RIBEIRO; BERETTA, VICTOR SPIANDOR; VITORIO, RODRIGO. Prefrontal Cortex Activity During Walking: Effects of Aging and Associations With Gait and Executive Function. NEUROREHABILITATION AND NEURAL REPAIR, AUG 2020. (14/22308-0, 16/21499-1)

CONCEICAO, NUBIA RIBEIRO; GOBBI, LILIAN TERESA BUCKEN; NOBREGA-SOUSA, PRISCILA; ORCIOLI-SILVA, DIEGO; BERETTA, VICTOR SPIANDOR; LIRANI-SILVA, ELLEN; OKANO, ALEXANDRE HIDEKI; VITORIO, RODRIGO. Aerobic Exercise Combined With Transcranial Direct Current Stimulation Over the Prefrontal Cortex in Parkinson Disease: Effects on Cortical Activity, Gait, and Cognition. NEUROREHABILITATION AND NEURAL REPAIR, MAY 2021. (14/22308-0, 16/21499-1)

ORCIOLI-SILVA, DIEGO; VITORIO, RODRIGO; NOBREGA-SOUSA, PRISCILA; DA CONCEICAO, NUBIA RIBEIRO; BERETTA, VICTOR SPIANDOR; LIRANI-SILVA, ELLEN; GOBBI, LILIAN TERESA BUCKEN. Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease. NEUROREHABILITATION AND NEURAL REPAIR, MAY 2020. (14/22308-0, 16/21499-1)

BERETTA, VICTOR SPIANDOR; CONCEICAO, NUBIA RIBEIRO; NOBREGA-SOUSA, PRISCILA; ORCIOLI-SILVA, DIEGO; BRAZ FONSECA DANTAS, LUANA KARLA; BUCKEN GOBBI, LILIAN TERESA; VITORIO, RODRIGO. Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson's disease: a systematic review. JOURNAL OF NEUROENGINEERING AND REHABILITATION, v. 17, n. 1, JUN 15 2020. (14/22308-0, 16/21499-1, 18/07385-9)

ORCIOLI-SILVA, DIEGO; VITORIO, RODRIGO; NOBREGA-SOUSA, PRISCILA; DA CONCEICAO, NUBIA RIBEIRO; BERETTA, VICTOR SPIANDOR; LIRANI-SILVA, ELLEN; GOBBI, LILIAN TERESA BUCKEN. Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease. NEUROREHABILITATION AND NEURAL REPAIR, v. 34, n. 7, p. 11-pg., 2020-05-25. (16/21499-1, 14/22308-0)

BERETTA, VICTOR SPIANDOR; VITORIO, RODRIGO; NOBREGA-SOUSA, PRISCILA; CONCEICAO, NUBIA RIBEIRO; ORCIOLI-SILVA, DIEGO; PEREIRA, MARCELO PINTO; BUCKEN GOBBI, LILIAN TERESA. Effect of Different Intensities of Transcranial Direct Current Stimulation on Postural Response to External Perturbation in Patients With Parkinson's Disease. NEUROREHABILITATION AND NEURAL REPAIR, v. 34, n. 11, p. 11-pg., 2020-10-01. (18/07385-9, 16/21499-1, 14/22308-0)

NOBREGA-SOUSA, PRISCILA; GOBBI, LILIAN TERESA BUCKEN; ORCIOLI-SILVA, DIEGO; DA CONCEICAO, NUBIA RIBEIRO; BERETTA, VICTOR SPIANDOR; VITORIO, RODRIGO. Prefrontal Cortex Activity During Walking: Effects of Aging and Associations With Gait and Executive Function. NEUROREHABILITATION AND NEURAL REPAIR, v. 34, n. 10, p. 10-pg., 2020-08-31. (14/22308-0, 16/21499-1)

ORCIOLI-SILVA, DIEGO; VITORIO, RODRIGO; NOBREGA-SOUSA, PRISCILA; BERETTA, VICTOR SPIANDOR; DA CONCEICAO, NUBIA RIBEIRO; OLIVEIRA, ANDERSON SOUZA; PEREIRA, MARCELO PINTO; BUCKEN GOBBI, LILIAN TERESA. Cortical Activity Underlying Gait Improvements Achieved With Dopaminergic Medication During Usual Walking and Obstacle Avoidance in Parkinson Disease. NEUROREHABILITATION AND NEURAL REPAIR, v. 35, n. 5, p. 13-pg., 2021-03-23. (16/21499-1, 17/19845-1, 14/22308-0)

CONCEICAO, NUBIA RIBEIRO; GOBBI, LILIAN TERESA BUCKEN; NOBREGA-SOUSA, PRISCILA; ORCIOLI-SILVA, DIEGO; BERETTA, VICTOR SPIANDOR; LIRANI-SILVA, ELLEN; OKANO, ALEXANDRE HIDEKI; VITORIO, RODRIGO. Aerobic Exercise Combined With Transcranial Direct Current Stimulation Over the Prefrontal Cortex in Parkinson Disease: Effects on Cortical Activity, Gait, and Cognition. NEUROREHABILITATION AND NEURAL REPAIR, v. 35, n. 8, p. 12-pg., 2021-05-28. (14/22308-0, 16/21499-1)

BERETTA, VICTOR SPIANDOR; ORCIOLI-SILVA, DIEGO; CONCEICA, NUBIA RIBEIRO; NOBREGA-SOUSA, PRISCILA; PEREIRA, SOUSA A MARCELO PINTO; GOBBI, LILIAN TERESA BUCKEN; VITORIO, RODRIGO. tDCS application for postural control in Parkinson's disease: Effects are associated with baseline characteristics. PARKINSONISM & RELATED DISORDERS, v. 93, p. 62-65, DEC 2021. (14/22308-0, 18/07385-9, 16/21499-1)

DE BELLI, VINICIUS; ORCIOLI-SILVA, DIEGO; BERETTA, VICTOR SPIANDOR; VITORIO, RODRIGO; ZAMPIER, VINICIUS CAVASSANO; NOBREGA-SOUSA, PRISCILA; DA CONCEIC, NUBIA RIBEIRO; GOBBI, LILIAN TERESA BUCKEN. Prefrontal Cortical Activity During Preferred and Fast Walking in Young and Older Adults: An fNIRS Study. Neuroscience, v. 473, p. 81-89, OCT 1 2021. (16/21499-1, 17/23476-1)