Natural compounds of interest: isolation, identification and evaluation of antimicrobial activity against phytopathogens.

• Grant number: 16/22228-1
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2017
• End date: February 28, 2019
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Wilson Roberto Cunha
• Grantee: Wilson Roberto Cunha
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
• City of the host institution: Franca
• Associated researchers: Carlos Henrique Gomes Martins ; Denise Crispim Tavares ; Márcio Luís Andrade e Silva

Abstract

Since the origin of agriculture, the creation of pest control methods has been a challenge for man. The diseases caused by pathogenic micro-organisms has caused significant losses in agriculture, grain destruction during storage, decreased nutritional value and sometimes produce harmful mycotoxins on humans and animals. The control of these diseases in agriculture has intensified, being carried out primarily through the use of synthetics compounds, but the indiscriminate use of these fungicides and bactericides have caused problems of human and environmental contamination, and also has caused the pathogens emergence of resistance to these products chemicals. Therefore, in the search for substitutes for synthetic compounds, natural products are an alternative of economic and ecological interest very promising, where the use of compounds extracted of natural sources and with a possible activity on phytopathogens inhibition could represent an option in the control of diseases in the field.This project aims to obtain some natural substances of interest, previously selected (ursolic acid, oleanolic acid, gipsogenic acid, sumaresinolic acid, rosmarinic acid and usnic acid) and evaluate them with respect to antimicrobial activity against some important phytopathogens. The extracts will be fractionated in order to obtain promising substances. Samples that show promising results will be assessed on kinetics of death and cytotoxicity, and will be formulated with solid dispersions aiming to optimize the results. (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

BOCALON, LUZIO G.; TOZATTI, MARCOS G.; JANUARIO, ANA H.; PAULETTI, PATRICIA M.; SILVA, MARCIO L. A.; ROCHA, LUCAS A.; MOLINA, EDUARDO F.; SANTOS, MARIO F. C.; CUNHA, WILSON R.. Incorporation of Betulinic Acid into Silica-Based Nanoparticles for Controlled Phytochemical Release. Analytical Letters, v. N/A, p. 15-pg., 2022-09-03. (16/22228-1, 13/20455-2)