Effects of exercises on secretions transport, inflammation, respiratory system strength and quality of life in patients with bronchiectasis

• Grant number: 16/20492-3
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2017
• End date: January 31, 2020
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Ada Clarice Gastaldi
• Grantee: Ada Clarice Gastaldi
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Ercy Mara Cipulo Ramos ; Hugo Celso Dutra de Souza ; José Antônio Baddini Martinez
• Associated scholarship(s): 18/07178-3 - Effects of exercise on secretion transport, inflammation, and quality of life in patients with noncystic fibrosis bronchiectasis, BP.TT

Abstract

Bronchiectasis are characterized by pathological and irreversible dilatation of the bronchi, and the perpetuation of inflammatory processes induced by chronic or recurrent infections that result in inefficient removal of secretions and microorganisms. Patients may benefit from physiotherapy to remove secretions, as well as global exercises in a rehabilitation program. The aim of this study is to evaluate the effects of exercise on the transport of secretions, inflammation, and resistance of the respiratory system, autonomic nervous system and its effects on the quality of life in patients with bronchiectasis inserted into a pulmonary rehabilitation program. They will be included 30 healthy volunteers and 30 with bronchiectasis, of both sexes, aged between 18-60 years. All will perform pulmonary function test; impulse oscillometry; analysis of the secretion properties; nasal transport time of saccharin; Cytokine analysis of the collection of nasal lavage and blood by enzyme immunoassay; condensate of exhaled expiration; exhaled nitric oxide; analysis of heart rate variability, and quality of life questionnaires. Volunteers will be randomly allocated to the pulmonary rehabilitation or control groups. In addition to the benefits for patients already know in the literature, the additional benefit of the removal of secretions in hypersecretive patients can contribute to optimizing the treatment e better control of the disease. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DOS SANTOS, DANIELE OLIVEIRA; DUTRA DE SOUZA, HUGO CELSO; BADDINI-MARTINEZ, JOSE ANTONIO; CIPULO RAMOS, ERCY MARA; GASTALDI, ADA CLARICE. Effects of exercise on secretion transport, inflammation, and quality of life in patients with noncystic fibrosis bronchiectasis Protocol for a randomized controlled trial. MEDICINE, v. 97, n. 7, FEB 2018. (16/20492-3)