Strategies on the synthesis of luminescent nanomaterials for the design of new multimodal optical sensors

• Grant number: 17/11764-2
• Support type: Regular Research Grants
• Duration: September 01, 2017 - August 31, 2019
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal researcher: Paulo Cesar de Sousa Filho
• Grantee: Paulo Cesar de Sousa Filho
• Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated grant(s): 18/08334-9 - New advanced materials for sensing applications: a collaborative project on structural and spectroscopic characterisation of novel rare-earth solids, AP.R SPRINT

Abstract

Rare earth (RE)-based nanomaterials are highly attractive as luminescent markers because of their unique spectroscopic properties, particularly for biological applications. In this sense, this project comprises the development of colloidal nanostructures acting as ratiometric luminescent sensors for reactive oxygen species (ROS) and as optical nanothermometers in biological systems. Initially, we propose the elaboration of new synthetic methodologies for colloidal nanoparticles using micro-heterogeneous systems, such as sacrificial templates and nanoreactors. Synthetic manipulation of REVO4, REPO4 and NaREF4 structures enables accurate description of spectroscopic properties with relation to structural, morphological and compositional parameters. This, in turn, allows for the design of nanothermometers or ROS ratiometric sensors with spatial and temporal resolution, which can afford stimuli responsive luminescence in single-particle scale. The combination of nanothermometry and ROS sensing is a highly interesting prospect towards multimodality and theranostics via the control of the surface functionality of the particles. Hence, luminescent sensors are potentially applicable as tools for the detailed study of cellular mechanisms associated to the oxidative stress of ROS and of related diseases. Therefore, we propose to strictly correlate the solid state properties of RE-based nanomaterials and their spectroscopic behavior, focusing on the design of new luminescent labeling methodologies applicable in intracellular conditions. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BRANDAO, SAMIRA G.; RIBEIRO, MARCOS A.; PERRELLA, V, RAFAEL; DE SOUSA FILHO, PAULO C.; LUZ, PRISCILLA P. Substituent effects on novel lanthanide(III) hydrazides complexes. JOURNAL OF RARE EARTHS, v. 38, n. 6, p. 642-648, JUN 2020. Web of Science Citations: 0.

PERRELLA, RAFAEL VIEIRA; DE SOUSA FILHO, PAULO CESAR. High-sensitivity dual UV/NIR-excited luminescence thermometry by rare earth vanadate nanoparticles. DALTON TRANSACTIONS, v. 49, n. 3, p. 911-922, JAN 21 2020. Web of Science Citations: 0.

COSTA, ROSIANE K. S.; TELES, STEFANI C.; DE SOUSA FILHO, PAULO C.; DIAS, ANDERSON; SIQUEIRA, KISLA P. F. Influence of europium doping on the structural phase-transition temperature of beta- and alpha - CoMoa(4) polymorphs. Materials Research Bulletin, v. 118, OCT 2019. Web of Science Citations: 0.

DE SOUSA FILHO, PAULO C.; ALAIN, JULIETTE; LEMENAGER, GODEFROY; LARQUET, ERIC; FICK, JOCHEN; SERRA, OSVALDO A.; GACOIN, THIERRY. Colloidal Rare Earth Vanadate Single Crystalline Particles as Ratiometric Luminescent Thermometers. Journal of Physical Chemistry C, v. 123, n. 4, p. 2441-2450, JAN 31 2019. Web of Science Citations: 3.

PAULO C. DE SOUSA FILHO; AYLA R. B.S. GALAÇO; OSVALDO A. SERRA. TERRAS RARAS: TABELA PERIÓDICA, DESCOBRIMENTO, EXPLORAÇÃO NO BRASIL E APLICAÇÕES. Química Nova, v. 42, n. 10, p. 1208-1224, Out. 2019.

VENTURINI FILHO, E.; DE SOUSA FILHO, P. C.; SERRA, O. A.; WEBER, I. T.; LUCENA, M. A. M.; LUZ, P. P. New luminescent lanthanide-based coordination compounds: Synthesis, studies of optical properties and application as marker for gunshot residues. Journal of Luminescence, v. 202, p. 89-96, OCT 2018. Web of Science Citations: 4.