Discussion of research projects involving chronic Hepatitis B and C antiviral treatment

• Grant number: 17/50042-2
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2017
• End date: July 31, 2019
• Field of knowledge: Health Sciences - Medicine
• Agreement: Emory University
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Suzane Kioko Ono
• Grantee: Suzane Kioko Ono
• Principal researcher abroad: Raymond Felix Schinazi
• Institution abroad: Emory University, United States
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 15/16291-0 - Frequency of polymorphisms in the genes responsible for the absorption, distribution, metabolism and excretion (ADME) of drugs in patients with Hepatocellular carcinoma and hepatitis C, AP.R

Abstract

This project is intended to support the mobility of researchers in order to implement scientific and scholarly collaboration between Department of Gastroenterology - University of Sao Paulo School of Medicine and Center for AIDS Research. Laboratory of Biochemical Pharmacology (LOBP), Department of Pediatrics. Emory University School of Medicine for the study of liver diseases. The researchers have been collaborating since 1997 in the study of liver diseases, specifically in the evaluation of antivirals for chronic hepatitis B wild and mutant variants that resulted in a publication in a high impact journal (Journal of Clinical investigation). Recently, in Brazil, the collaboration extended to supervision of Graduate and Medical students from University of São Paulo School of Medicine through PhD sandwich program and Graduation International interchange program. Further collaboration for the study of liver diseases is being planned between the two universities. In particular, the discussion of the results of the first panel of ADME (absorption, distribution, metabolism and excretion) gene polymorphic from patients with chronic hepatitis (FAPESP project approved) and discuss protocols for future collaboration in order to consolidate partnership. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ABREU, RODRIGO M.; BASSIT, LEDA C.; TAO, SIJIA; JIANG, YONG; FERREIRA, ALINE S.; HORI, PATRICIA CA; GANOVA-RAEVA, LILIA M.; KHUDYAKOV, YURY; SCHINAZI, RAYMOND F.; CARRILHO, FLAIR J.; et al. Long-term virological and adherence outcomes to antiviral treatment in a 4-year cohort chronic HBV study. ANTIVIRAL THERAPY, v. 24, n. 8, p. 13-pg., 2019-01-01. (17/50042-2)

BASSIT, LEDA; ONO, SUZANE KIOKO; SCHINAZI, RAYMOND F.; LIU, X; ZHAN, P; MENENDEZARIAS, L; POONGAVANAM, V. Moving Fast Toward Hepatitis B Virus Elimination. ANTIVIRAL DRUG DISCOVERY AND DEVELOPMENT, v. 1322, p. 24-pg., 2021-01-01. (17/50042-2)