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Influence of the immunological profile on sustained virological response of patients with chronic Hepatitis during therapy with direct acting antivirals

Grant number: 16/25416-3
Support type:Regular Research Grants
Duration: October 01, 2017 - September 30, 2019
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Giovanni Faria Silva
Grantee:Giovanni Faria Silva
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Assoc. researchers: Fernanda Cristina Winckler ; Márjorie de Assis Golim

Abstract

Chronic hepatitis C is one of the major causes of cirrhosis and hepatocellular carcinoma. The response to treatment in cirrhotics from PegIFN-based therapy is poor, thus the new options of treatment with direct acting antivirals (DAAs) continue showing decreased rates of sustained virological response (SVR), mainly in advanced cirrhosis. Some hypotheses are: impaired pharmacokinetics, possible existence of viral reservoirs in hepatocytes and especially the marked effects of cirrhosis on immune responses resulting in weak host response. The objective of this study will be to evaluate the influence of the inflammatory response in SVR in cirrhotic patients (F4) and non-cirrhotic (F3 and dF2) treated with DAAs. One hundred and ninety patients with hepatitis C under treatment with DAAs of Viral Hepatitis Outpatient Clinic of UNESP in Botucatu will be included. Exclusion criteria: coinfected, active hepatocellular carcinoma, pregnant women and alcohol and drug users. Clinical, epidemiological and biochemical parameters will be recorded and blood collection will be performed in 2 tubes in each of the following moments: pre-treatment and 12 weeks after the end of treatment. The analyzes will be performed by flow cytometry for Immunophenotyping of Natural Killer and Monocyte cells, CD4 and CD8 quantification, and cytokine and chemokine dosing by CBA method. (AU)