Sialadenitis in Sjögren's Syndrome and lupus erythematosus: clinical-pathological correlation and proteomic and metabolomic analysis of saliva

• Grant number: 17/11806-7
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2017
• End date: March 31, 2020
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Silvia Vanessa Lourenço
• Grantee: Silvia Vanessa Lourenço
• Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Milena Monteiro de Souza Antunes ; Sheyla Batista Bologna Lopes

Abstract

Xerostomia is characterised as a subjective dry mouth feeling which can be a consequence of reducing or interrupting salivary gland function. This condition composes a complex exocrinopathy responsible for damaging salivary glands in Sjogren's syndrome (SS) and also in Lupus Erythematosus (LE). The pathogeny of xerostomia in both diseases remains unclear. For two years, our group performed a clinical-pathological investigation concerning basic differences of xerostomia in SS and LE, confirming the presence of significant complications in the referred salivary glands. The present research aims to further investigatethese alterations, now comparing differences in salivary fluid and in the glandular tissue in SS and LE, attempting to correlate their morphology and biochemical composition. Basically this study will include histopathological analysis of minor salivary glands of SS and LE patients and correlate these results to dry mouth complaint in order to verify possible alterations in the excretory duct function. Furthermore, biochemical assays will be performed on salivary secretion collected from those patients and then the expression of its proteins will be interpreted through proteomic analysis and its metabolites through metabolomic analysis. As a consequence of this study, our results might be able to contribute for a novel classification of xerostomia in distinct diseases, impacting on the therapeutic and on the diagnostic process. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SOUZA, M. M.; FLOREZI, G. P.; NICO, M. M. S.; DE PAULA, F.; PAULA, F. M.; LOURENCO, S. V.. Salivary proteomics in lichen planus: A relationship with pathogenesis?. ORAL DISEASES, v. 24, n. 5, p. 784-792, JUL 2018. (14/11020-5, 17/11806-7)

BOLOGNA, SHEYLA B.; CAVALCANTE, WANESSA S.; FLOREZI, GIOVANNA P.; SOUZA, MILENA M.; NICO, MARCELLO M. S.; LOURENCO, SILVIA V.. Distinct Salivary Gland Features in Sjogren's Syndrome and Lupus Erythematosus Sialadenite. AMERICAN JOURNAL OF DERMATOPATHOLOGY, v. 42, n. 6, p. 407-413, JUN 2020. (14/15214-9, 17/11806-7)

BOLOGNA, S. B.; NICO, M. M. S.; FLOREZI, G.; CAVALCANTE, W. S.; LOURENCO, V, S.. Peculiar histopathological features in minor salivary gland in lupus erythematosus. Lupus, v. 27, n. 10, p. 1706-1711, SEP 2018. (17/11806-7)