Development of controlled release system for topic aplication of cosmetic active ingredients, using a scalable electrospinning setup

• Grant number: 17/06268-6
• Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE
• Start date: November 01, 2018
• End date: January 31, 2021
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Agreement: EMBRAPII
• Principal Investigator: Adriano Marim de Oliveira
• Grantee: Adriano Marim de Oliveira
• Host Institution: Instituto de Pesquisas Tecnológicas S/A (IPT). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São Paulo , SP, Brazil
• Company: Ananse Química Ltda
• City: São Paulo
• Pesquisadores principais: Kleber Lanigra Guimarães ; Maria Helena Ambrosio Zanin ; Natália Neto Pereira Cerize
• Associated researchers: Denivaldo Ribeiro Mota ; Renato Rosafa Gavioli
• Associated research grant(s): 17/26372-2 - Multi-user euipament approved in grant 2017/06268-6: Equipamento de eletrofiação em escala laboratorial da fabricante Inovenso, modelo Nanospinner24-XP, AP.EMU
• Associated scholarship(s): 18/00533-2 - Training in characterization of polymer solutions and electrospun products, BP.TT

Abstract

This project has as main objective to develop process for obtaining nanofibers based on polymeric materials via electrospinning technique for building delivery systems for cosmetics actives employing infrastructure capable of scaling. More specifically, it is aimed the generation of nanofibers employing polymer solutions of alginate, polyvinylpyrrolidone (PVP) and polymethylmethacrylate (PMMA) as main constituents of the matrix encapsulating of hydrophilic active (Vitamin B3) and hydrophobic active (Vitamin E) to cosmetics application in face masks. The project will be conducted in a single phase, developed in laboratory scale. The activities will be carried out in 4 different stages: 1) Bibliographic survey, acquisition of raw materials and acquisition and installation of infrastructure; 2) Generation and characterization of samples in the absence of actives; 3) Generation and characterization of samples containing encapsulated actives; 4) Performance evaluation. (AU)