The effect of global change on bat immune response: an experimental approach

• Grant number: 17/17607-6
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• Start date: March 08, 2018
• End date: December 07, 2018
• Field of knowledge: Biological Sciences - Zoology - Physiology of Recent Groups
• Principal Investigator: Ariovaldo Pereira da Cruz-Neto
• Grantee: Ariovaldo Pereira da Cruz-Neto
• Visiting researcher: Luis Gerardo Herrera Montalvo
• Visiting researcher institution: Universidad Nacional Autónoma de México, Coyoacán (UNAM), Mexico
• Host Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil
• Associated research grant: 14/16320-7 - Impacts of climate/environmental change on the fauna: an integrative approach, AP.PFPMCG.TEM

Abstract

Climate and land-use changes are two of the most important anthropogenic hazards to global biodiversity. These changes have triggered an unprecedented rate of disease emergence in wildlife warranting for physiological studies that explore how animals deal with pathogens in current and predicted scenarios. Changes in ambient temperature and food availability are two of the most important consequences of climate and land-use but their synergic effect on immune response has been rarely examined. Bats represent a promising model to examine the effect of climate and land-use changes in immune response because they are reservoirs of a number of infectious diseases whose spread may be related to physiological stress associated with these ambient alterations. I propose to examine the physiology of bat immune response in relation to experimental manipulation of conditions that are likely to be affected by climate and land-use changes: ambient temperature and food availability. In particular, I will examine the effect of diet and ambient temperature and the synergy of these two factors on the acute phase response (APR) of a fruit-eating bat (Carollia perspicillata). I will stimulate the APR in this bat under different diet-temperature treatments, and measure body temperature, number of leukocytes, neutrophils and lymphocytes, and bacterial killing ability. I predict that the synergic effects of high ambient temperature and reduced food availability will result in lack of pyrogenic response, decrease counts of leukocytes, neutrophills, and lymphocytes, and declined bacterial killing ability. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CRESTANI, ANA C.; PIZO, MARCO A.; FONTANELLA, ANTONIO B. A.; HERRERA M, L. GERARDO; CRUZ-NETO, ARIOVALDO P.. ugar and nitrogen digestive processing does not explain the specialized relationship between euphonias and low-quality fruit. JOURNAL OF AVIAN BIOLOGY, v. 52, n. 11, OCT 2021. (14/16320-7, 13/26089-8, 17/17607-6)

MELHADO, GABRIEL; PEDROBOM L, JORGE HENRIQUE; MENEGARIO, AMAURI A.; HERRERA MONTALVO, LUIS GERARDO; CRUZ-NETO, ARIOVALDO P.. Lead exposure does not affect baseline and induced innate immunity in quails. OURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOG, v. 337, n. 5, p. 10-pg., 2022-02-21. (14/16320-7, 17/17607-6)