Secular trends, spatial evolution, and maternal & neonatal conditions associated to early and late neonatal deaths caused by respiratory distress, perinatal asphyxia, infections, and congenital anomalies, in São Paulo State, Brazil, between 2002 and 2015

• Grant number: 17/03748-7
• Support Opportunities: Research Projects - Thematic Grants
• Start date: December 01, 2017
• End date: November 30, 2025
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Agreement: Fundação Seade
• Principal Investigator: Ruth Guinsburg
• Grantee: Ruth Guinsburg
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Principal investigators: Carlos Roberto Veiga Kiffer ; Maria Fernanda Branco de Almeida
• Associated researchers: Daniela Testoni Costa Nobre ; Kelsy Catherina Nema Areco ; Mandira Daripa Kawakami ; Milton Harumi Miyoshi ; Paulo Bandiera Paiva ; Rita de Cássia Xavier Balda
• Associated scholarship(s): 19/10520-8 - Spatial evolution of early and late neonatal mortality associated to respiratory disorders, infections, congenital anomalies and perinatal asphyxia in the State of São Paulo between 2002 and 2015, BP.PD

Abstract

The comprehension of the evolution of neonatal mortality by analyzing its main causes, its temporal and geographical distribution and the demographic variables associated to these deaths could help to design strategies to achieve the Sustainable Development Goals, established by the United Nations in 2015.Objective: To analyze non-aleatory patterns of secular trends, spatial evolution, and maternal and neonatal conditions associated to neonatal deaths caused by prematurity, respiratory distress, perinatal asphyxia, infections, and congenital anomalies, in São Paulo State, Brazil, between 2002 and 2015.Method: Populational cohort study of live born infants between 2002-2015, in São Paulo State, Brazil, classified in two groups: Those that died between 0-27 days and those alive at the 27th day of life (estimate: 8,400,000 births and 75,000 neonatal deaths). Regarding the deaths, the source will be the linkage of SEADE Foundation databases of births and death registries, analyzed by: 1) Secular trend of neonatal deaths by mathematical exponential or polynomial modelling; 2) Spatial analysis in order to verify non-aleatory patterns of neonatal deaths in geographic units of São Paulo State during the passage of time; 3) Evaluation of the risk factors associated with neonatal death by conditional logistic regression after pairing each death to a similar live newborn. All approaches will follow the cause of death (prematurity, respiratory distress, perinatal asphyxia, infections, and congenital anomalies) and age at death (1st hour, 1st 24 hours, 0-6 days, and 7-27 days after birth). (AU)

Scientific publications

(10)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

SCAVACINI MARINONIO, ANA SILVIA; COSTA-NOBRE, DANIELA TESTONI; MIYOSHI, MILTON HARUMI; XAVIER BALDA, RITA DE CASSIA; NEMA ARECO, KELSY CATHERINA; KONSTANTYNER, TULIO; KAWAKAMI, MANDIRA DARIPA; SANUDO, ADRIANA; BANDIERA-PAIVA, PAULO; VIEIRA DE FREITAS, ROSA MARIA; et al. Clusters of preterm live births and respiratory distress syndrome-associated neonatal deaths: spatial distribution and cooccurrence patterns. BMC PUBLIC HEALTH, v. 22, n. 1, p. 10-pg., 2022-06-20. (17/03748-7)

GUINSBURG, RUTH; SANUDO, ADRIANA; KIFFER, V, CARLOS ROBERTO; MARINONIO, ANA SILVIA S.; COSTA-NOBRE, DANIELA T.; ARECO, KELSY N.; KAWAKAMI, MANDIRA D.; MIYOSHI, MILTON H.; BANDIERA-PAIVA, PAULO; BALDA, RITA DE CASSIA X.; et al. Annual trend of neonatal mortality and its underlying causes: population-based study - Sao Paulo State, Brazil, 2004-2013. BMC PEDIATRICS, v. 21, n. 1, JAN 26 2021. (17/03748-7)

SCAVACINI MARINONIO, ANA SILVIA; COSTA-NOBRE, DANIELA TESTONI; SANUDO, ADRIANA; MIYOSHI, MILTON HARUMI; NEMA ARECO, KELSY CATHERINA; KAWAKAMI, MANDIRA DARIPA; XAVIER, RITA DE CASSIA; KONSTANTYNER, TULIO; BANDIERA-PAIVA, PAULO; VIEIRA DE FREITAS, ROSA MARIA; et al. Temporal Trend and Risk Factors for Respiratory Distress Syndrome-Associated Neonatal Mortality in Preterm Infants: A Population-Based Study in a Middle-Income Country. AMERICAN JOURNAL OF PERINATOLOGY, v. N/A, p. 7-pg., 2022-08-16. (17/03748-7)

OLIVEIRA, CARINA NUNES VIEIRA E; KONSTANTYNER, TULIO; COSTA-NOBRE, DANIELA TESTONI; MARINONIO, ANA SILVIA SCAVACINI; KAWAKAMI, MANDIRA DARIPA; BALDA, RITA DE CASSIA XAVIER; MIYOSHI, MILTON HARUMI; SANUDO, ADRIANA; ARECO, KELSY CATHERINA NEMA; BANDIERA-PAIVA, PAULO; et al. Live births and deaths of neonates born to adolescent mothers: analysis of trends and associations from a population study in a region of a middle-income country. BMC PREGNANCY AND CHILDBIRTH, v. 25, n. 1, p. 11-pg., 2025-02-19. (17/03748-7)

ARECO, KELSY N.; KONSTANTYNER, TULIO; BANDIERA-PAIVA, PAULO; BALDA, RITA C. X.; COSTA-NOBRE, DANIELA T.; SANUDO, ADRIANA; KIFFER, CARLOS ROBERTO V.; KAWAKAMI, MANDIRA D.; MIYOSHI, MILTON H.; MARINONIO, ANA SILVIA SCAVACINI; et al. Operational Challenges in the Use of Structured Secondary Data for Health Research. FRONTIERS IN PUBLIC HEALTH, v. 9, JUN 15 2021. (17/03748-7)

MARINONIO, ANA SILVIA SCAVACINI; MIYOSHI, MILTON HARUMI; COSTA-NOBRE, DANIELA TESTONI; SANUDO, ADRIANA; ARECO, KELSY CATHERINA NEMA; KAWAKAMI, MANDIRA DARIPA; BALDA, RITA DE CASSIA XAVIER; KONSTANTYNER, TULIO; BANDIERA-PAIVA, PAULO; DE FREITAS, ROSA MARIA VIEIRA; et al. Congenital diaphragmatic hernia in a middle-income country: Persistent high lethality during a 12-year period. PLoS One, v. 18, n. 2, p. 12-pg., 2023-02-10. (17/03748-7)

COSTA-NOBRE, DANIELA TESTONI; MARINONIO, ANA SILVIA SCAVACINI; MIYOSHI, MILTON HARUMI; SANUDO, ADRIANA; ARECO, KELSY CATHERINA NEMO; KAWAKAMI, MANDIRA DARIPA; BALDA, RITA DE CASSIA XAVIER; KONSTANTYNER, TULIO; VIEIRA E OLIVEIRA, CARINA NUNES; BANDIERA-PAIVA, PAULO; et al. Space scan statistics to identify clusters of neonatal mortality associated with bacterial sepsis. EPIDEMIOLOGY AND INFECTION, v. 152, p. 3-pg., 2024-12-13. (17/03748-7)

ARECO, KELSY N.; BANDIERA-PAIVA, PAULO; BALDA, RITA C. X.; COSTA-NOBRE, DANIELA T.; MARINONIO, ANA SILVIA SCAVACINI; SANUDO, ADRIANA; KAWAKAMI, MANDIRA D.; MIYOSHI, MILTON H.; OLIVEIRA, CARINA NUNES VIEIRA E.; FREITAS, ROSA M. V.; et al. Development and validation of an epidemiological risk score for neonatal death in a middle-income country. FRONTIERS IN PUBLIC HEALTH, v. 13, p. 18-pg., 2025-11-19. (17/03748-7)

MARINONIO, ANA SILVIA SCAVACINI; MIYOSHI, MILTON HARUMI; NOBRE, DANIELA TESTONI COSTA; SANUDO, ADRIANA; ARECO, KELSY CATHERINA NEMA; KAWAKAMI, MANDIRA DARIPA; BALDA, RITA DE CASSIA XAVIER; KONSTANTYNER, TULIO; VIEIRA E OLIVEIRA, CARINA NUNES; BANDIERA-PAIVA, PAULO; et al. Neonatal mortality of live births with congenital diaphragmatic hernia in São Paulo State, Brazil: Failure of care?. Revista Paulista de Pediatria, v. 43, p. 8-pg., 2025-01-01. (17/03748-7)

KONSTANTYNER, TULIO; ARECO, KELSY CATHERINA NEMA; BANDIERA-PAIVA, PAULO; MARINONIO, ANA SILVIA SCAVACINI; KAWAKAMI, MANDIRA DARIPA; BALDA, RITA DE CASSIA XAVIER; MIYOSHI, MILTON HARUMI; SANUDO, ADRIANA; COSTA-NOBRE, DANIELA TESTONI; DE FREITAS, ROSA MARIA VIEIRA; et al. The burden of inappropriate birth weight on neonatal survival in term newborns: a population-based study in a middle-income setting. FRONTIERS IN PEDIATRICS, v. 11, p. 8-pg., 2023-06-08. (17/03748-7)