Effects of transcranial direct current stimulation (tDCS) on breathing variability and post-exercise hypotension in resistant hypertensive subjects

• Grant number: 17/21320-4
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2018
• End date: August 31, 2020
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Bruno Rodrigues
• Grantee: Bruno Rodrigues
• Host Institution: Faculdade de Educação Física (FEF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Heitor Moreno Junior ; Lígia de Moraes Antunes Corrêa ; Maria Andréia Delbin

Abstract

Resistant hypertension (RH) is a complex and multifactorial disease and has been associated with sympathetic nervous system hyperactivity (SNS) and reduction of vagal activity. Increasing the complexity of understanding their pathophysiological mechanisms, recent studies have demonstrated relationships between the autonomic and immune systems. Invasive therapies, as well as physical exercise protocols, have been developed for the treatment of RH; however, hyperactivity of the SNS still remains a challenge for the blood pressure (BP) control. Thus, the use of cerebral stimulation techniques, such as non-invasive transcranial direct current stimulation (tDCS) on the cerebral cortex of RH subjects seems promising due to potential modulation of BP levels. Previous studies have shown that cortical sympathetic modulation by tDCS may reduce blood pressure levels, improve autonomic function and exercise capacity; however, the main outcomes were associated with improved psychic depression in non-RH patients, as well as with the performance of athletes. Thus, the current randomized clinical trial aims to evaluate in RH patients: 1) the presence of periodic breathing and breathing variability during exercise, as well as to test the effects of tDCS on these variables; 2) the effects of tDCS on aerobic post-exercise hypotension; 3) the effects of 10 sessions (2 weeks) of tDCS, controlled by placebo-sham, on hemodynamic, autonomic, inflammatory and ventilatory variables (during the ergospirometry). We hypothesized that tDCS may positively modulate cardiorespiratory responses during an exercise test and potentiate hypotensive effects of exercise, possibly mediated by autonomic, biochemical and inflammatory changes. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARBOZA, CATARINA DE ANDRADE; MOURA, ELIEZER GUIMARAES; MINISTRO, GABRIELA; CASTANO, JAVIER BEDOYA; SILVA SANTOS, GABRIELA C.; DIAS JUNIOR, GILMAR; MORENO JUNIOR, HEITOR; RODRIGUES, BRUNO. Central blood pressure and aortic pulse wave reflection in water-exercised postmenopausal hypertensive women: A cross-sectional study. Experimental Gerontology, v. 143, JAN 2021. (17/24726-1, 17/21320-4)

COELHO-JUNIOR, HELLO JOSE; ASANO, RICARDO YUKIO; GONCALVEZ, IVAN DE OLIVEIRA; BRIETZKE, CAYQUE; PIRES, FLAVIO OLIVEIRA; AGUIAR, SAMUEL DA SILVA; FERIANI, DANIELE JARDIM; CAPERUTO, ERICO CHAGAS; UCHIDA, MARCO CARLOS; RODRIGUES, BRUNO. Multicomponent exercise decreases blood pressure, heart rate and double product in normotensive and hypertensive older patients with high blood pressure. ARCHIVOS DE CARDIOLOGIA DE MEXICO, v. 88, n. 5, p. 413-422, DEC 2018. (17/21320-4)

COELHO-JUNIOR, HELIO JOSE; GONCALVEZ, IVAN DE OLIVEIRA; SANCHES, IRIS CALLADO; GONCALVES, LEANDRO; CAPERUTO, ERICO CHAGAS; UCHIDA, MARCO CARLOS; RODRIGUES, BRUNO. Multicomponent Exercise Improves Physical Functioning but Not Cognition and Hemodynamic Parameters in Elderly Osteoarthritis Patients Regardless of Hypertension. BIOMED RESEARCH INTERNATIONAL, 2018. (17/21320-4)

COELHO-JUNIOR, HELLO J.; GONCALVES, IVAN DE OLIVEIRA; CAMARA, NIELS O. S.; CENEDEZE, MARCO A.; BACURAU, REURY F.; ASANO, RICARDO YUKIO; SANTANA, JEFERSON; CAPERUTO, ERICO; UCHIDA, MARCO C.; RODRIGUES, BRUNO. Non-periodized and Daily Undulating Periodized Resistance Training on Blood Pressure of Older Women. FRONTIERS IN PHYSIOLOGY, v. 9, NOV 27 2018. (17/21320-4)

GAMBASSI, BRUNO BAVARESCO; COELHO-JUNIOR, HELLO JOSE; DOS SANTOS, CAMILA PAIXAO; GONCALVES, IVAN DE OLIVEIRA; MOSTARDA, CRISTIANO TEIXEIRA; MARZETTI, EMANUELE; SOTAO, SAMIR SEGUINS; UCHIDA, MARCO CARLOS; DE ANGELIS, KATIA; RODRIGUES, BRUNO. Dynamic Resistance Training Improves Cardiac Autonomic Modulation and Oxidative Stress Parameters in Chronic Stroke Survivors: A Randomized Controlled Trial. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2019, NOV 20 2019. (17/21320-4)

PIRES, NAYARA FRACCARI; COELHO-JUNIOR, HELIO JOSE; GAMBASSI, BRUNO BAVARESCO; CABRAL DE FARIA, ANA PAULA; VERSUTI RITTER, ALESSANDRA MILENI; BARBOZA, CATARINA DE ANDRADE; FERREIRA-MELO, SILVIA ELAINE; RODRIGUES, BRUNO; MORENO JUNIOR, HEITOR. Combined Aerobic and Resistance Exercises Evokes Longer Reductions on Ambulatory Blood Pressure in Resistant Hypertension: A Randomized Crossover Trial. Cardiovascular Therapeutics, v. 2020, AUG 1 2020. (17/21320-4, 16/18104-5)

COELHO-JUNIOR, HELIO JOSE; GONCALVEZ, IVAN DE OLIVEIRA; SANCHES, IRIS CALLADO; GONCALVES, LEANDRO; CAPERUTO, ERICO CHAGAS; UCHIDA, MARCO CARLOS; RODRIGUES, BRUNO. Multicomponent Exercise Improves Physical Functioning but Not Cognition and Hemodynamic Parameters in Elderly Osteoarthritis Patients Regardless of Hypertension. BIOMED RESEARCH INTERNATIONAL, v. 2018, p. 10-pg., 2018-01-01. (17/21320-4)

COELHO-JUNIOR, HELIO JOSE; GAMBASSI, BRUNO BAVARESCO; IRIGOYEN, MARIA-CLAUDIA; GONCALVES, IVAN DE OLIVEIRA; LAUANDE OLIVEIRA, PAULA DE LOURDES; SCHWINGEL, PAULO ADRIANO; LOPES ALVES, CANDIDA HELENA; ASANO, RICARDO YUKIO; UCHIDA, MARCO CARLOS; RODRIGUES, BRUNO. Hypertension, Sarcopenia, and Global Cognitive Function in Community-Dwelling Older Women: A Preliminary Study. JOURNAL OF AGING RESEARCH, v. 2018, p. 8-pg., 2018-01-01. (17/21320-4)